DegronMD - Q01433(AMPD2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G201C	TCGA-36-2543	OV	TCGA	LQLYKE	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.2778
p.E202D	TCGA-98-8023	LUSC	TCGA	LQLYKE	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.25
p.D206E	TCGA-D1-A103	UCEC	TCGA	LQLYKE	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.1389
p.R207Q	TCGA-DI-A0WH	UCEC	TCGA	LQLYKE	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.1111
p.R207Q	SIDM00096	T-Cell Non-Hodgkin's Lymphoma	GDSC	LQLYKE	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.1111
p.R207Q	ACH-000338	Lymphoma	CCLE	LQLYKE	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.1111
p.R207Q	SR	haematopoietic and lymphoid tissue	COSMIC	LQLYKE	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.1111
p.G201D	DO224772	COCA	ICGC	LQLYKE	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.2778
p.G198V	DO233804	GACA	ICGC	LQLYKE	LIG_APCC_ABBA_1	194:199	Mutation altering degron motif	0.7532
p.E189G	DO220423	KICH	ICGC	LQLYKE	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.1944
p.M206L	DO231566	LINC	ICGC	LQLYKE	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.1389
p.R205H	DO51407	PRAD	ICGC	LQLYKE	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.1667
p.R205H	DO40900	UCEC	ICGC	LQLYKE	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.1667
p.D191E	SIDM01237	Hepatocellular Carcinoma	GDSC	LQLYKE	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.25
p.D191E	ACH-001021	Liver Cancer	CCLE	LQLYKE	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.25
p.D191E	C3A	liver	COSMIC	LQLYKE	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.25
p.R207W	SIDM01739	Small Cell Lung Carcinoma	GDSC	LQLYKE	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.1111
p.H187R	SNU-C5	large intestine	COSMIC	LQLYKE	LIG_APCC_ABBA_1	194:199	Mutation blocking ubiquitination signal	0.5833
p.R205C	SNU-1040	large intestine	COSMIC	LQLYKE	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.1667
p.R206C	SNU-1040	large intestine	COSMIC	LQLYKE	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.1389
p.H186R	SNU-C5	large intestine	COSMIC	LQLYKE	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.1111

Kaplan plot for AMPD2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AMPD2

UniProt ID: Q01433

Entrez ID: 271

Protein name: AMP deaminase 2 (EC 3.5.4.6) (AMP deaminase isoform L)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AMPD2 in