DegronMD

Uniprot ID: Q01433

Source protein: AMP deaminase 2

Source gene: AMPD2

Class: LIG_APCC_ABBA_1

Location: 194:199

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8507

ASA_SCORE: 90.5333

COIL: 0.3487

CONS_SCORE: 0.2883

DSS_SCORE: 0.5768

HELIX: 0.5758

FCONS_SCORE: 0.9913

RIG_SCORE: 0.7521

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G201C	TCGA-36-2543	OV	TCGA	LQLYKE	LIG_APCC_ABBA_1	0.2778
p.E202D	TCGA-98-8023	LUSC	TCGA	LQLYKE	LIG_APCC_ABBA_1	0.25
p.D206E	TCGA-D1-A103	UCEC	TCGA	LQLYKE	LIG_APCC_ABBA_1	0.1389
p.R207Q	TCGA-DI-A0WH	UCEC	TCGA	LQLYKE	LIG_APCC_ABBA_1	0.1111
p.R207Q	SIDM00096	T-Cell Non-Hodgkin's Lymphoma	GDSC	LQLYKE	LIG_APCC_ABBA_1	0.1111
p.R207Q	ACH-000338	Lymphoma	CCLE	LQLYKE	LIG_APCC_ABBA_1	0.1111
p.R207Q	SR	haematopoietic_and_lymphoid_tissue	COSMIC	LQLYKE	LIG_APCC_ABBA_1	0.1111
p.G201D	DO224772	COCA	ICGC	LQLYKE	LIG_APCC_ABBA_1	0.2778
p.G198V	DO233804	GACA	ICGC	LQLYKE	LIG_APCC_ABBA_1	0.7532
p.E189G	DO220423	KICH	ICGC	LQLYKE	LIG_APCC_ABBA_1	0.1944
p.M206L	DO231566	LINC	ICGC	LQLYKE	LIG_APCC_ABBA_1	0.1389
p.R205H	DO51407	PRAD	ICGC	LQLYKE	LIG_APCC_ABBA_1	0.1667
p.R205H	DO40900	UCEC	ICGC	LQLYKE	LIG_APCC_ABBA_1	0.1667
p.D191E	SIDM01237	Hepatocellular Carcinoma	GDSC	LQLYKE	LIG_APCC_ABBA_1	0.25
p.D191E	ACH-001021	Liver Cancer	CCLE	LQLYKE	LIG_APCC_ABBA_1	0.25
p.D191E	C3A	liver	COSMIC	LQLYKE	LIG_APCC_ABBA_1	0.25
p.R207W	SIDM01739	Small Cell Lung Carcinoma	GDSC	LQLYKE	LIG_APCC_ABBA_1	0.1111
p.H187R	SNU-C5	large_intestine	COSMIC	LQLYKE	LIG_APCC_ABBA_1	0.5833
p.R205C	SNU-1040	large_intestine	COSMIC	LQLYKE	LIG_APCC_ABBA_1	0.1667
p.R206C	SNU-1040	large_intestine	COSMIC	LQLYKE	LIG_APCC_ABBA_1	0.1389
p.H186R	SNU-C5	large_intestine	COSMIC	LQLYKE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01433	AMP deaminase 2	LIG_APCC_ABBA_1	194:199	LQLYKE	APC,CDC20,FZR1	0.8507	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons