DegronMD - Q01813(PFKP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E18K	TCGA-5P-A9KC	KIRP	TCGA	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.591
p.E18K	DO223954	KIRP	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.591
p.R18C	DO219735	CESC	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.8301
p.P9L	DO8159	COAD	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.2222
p.P9L	DO47267	SKCM	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.2222
p.A13V	DO10443	COAD	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.6936
p.A13V	DO47849	STAD	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.6936
p.A13V	DO41638	UCEC	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.6936
p.R11C	DO233634	GACA	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.2778
p.C7S	DO228194	LICA	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1667
p.R6L	DO228971	LICA	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation blocking phosphorylation signal	0.5833
p.G24V	DO229018	LICA	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.25
p.G11D	DO50970	LICA	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.2778
p.Y16C	DO23858	LUAD	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.7087
p.G24D	DO25927	LUAD	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.25
p.P9S	DO222847	MELA	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.2222
p.G15V	DO37921	SKCM	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.7532
p.G20D	DO38328	STAD	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.7198
p.R8H	DO40996	UCEC	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1944
p.R8H	SCC-15	upper aerodigestive tract	COSMIC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1944
p.R6C	DO41871	UCEC	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation blocking phosphorylation signal	0.5833
p.R18H	DO41235	UCEC	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.8244
p.G15E	DO41271	UCEC	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.7199
p.A8V	SIDM00334	Endometrial Carcinoma	GDSC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1944
p.A8V	ACH-000879	Endometrial/Uterine Cancer	CCLE	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1944
p.G24C	ACH-000911	Gastric Cancer	CCLE	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.25
p.A3P	ACH-001345	Colon/Colorectal Cancer	CCLE	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.0556
p.I23V	DEL	haematopoietic and lymphoid tissue	COSMIC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.2778
p.H25Q	GP5d	large intestine	COSMIC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation blocking ubiquitination signal	0.6667
p.E25D	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation blocking ubiquitination signal	0.6667
p.A16S	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.7588
p.H14L	EKVX	lung	COSMIC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.7313
p.I23F	MCC13	skin	COSMIC	LRKFLEHLS	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.2778

Kaplan plot for PFKP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PFKP

UniProt ID: Q01813

Entrez ID: 5214

Protein name: ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PFKP in