DegronMD

Uniprot ID: Q01813

Source protein: ATP-dependent 6-phosphofructokinase, platelet type

Source gene: PFKP

Class: DEG_APCC_DBOX_1

Location: 13:21

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.789

ASA_SCORE: 93.8333

COIL: 0.682

CONS_SCORE: 0.1989

DSS_SCORE: 0.3748

HELIX: 0.2271

FCONS_SCORE: 0.6261

RIG_SCORE: 0.7608

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E18K	TCGA-5P-A9KC	KIRP	TCGA	LRKFLEHLS	DEG_APCC_DBOX_1	0.591
p.E18K	DO223954	KIRP	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	0.591
p.R18C	DO219735	CESC	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	0.8301
p.P9L	DO8159	COAD	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	0.2222
p.P9L	DO47267	SKCM	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	0.2222
p.A13V	DO10443	COAD	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	0.6936
p.A13V	DO47849	STAD	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	0.6936
p.A13V	DO41638	UCEC	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	0.6936
p.R11C	DO233634	GACA	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	0.2778
p.C7S	DO228194	LICA	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	0.1667
p.R6L	DO228971	LICA	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	0.5833
p.G24V	DO229018	LICA	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	0.25
p.G11D	DO50970	LICA	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	0.2778
p.Y16C	DO23858	LUAD	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	0.7087
p.G24D	DO25927	LUAD	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	0.25
p.P9S	DO222847	MELA	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	0.2222
p.G15V	DO37921	SKCM	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	0.7532
p.G20D	DO38328	STAD	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	0.7198
p.R8H	DO40996	UCEC	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	0.1944
p.R8H	SCC-15	upper_aerodigestive_tract	COSMIC	LRKFLEHLS	DEG_APCC_DBOX_1	0.1944
p.R6C	DO41871	UCEC	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	0.5833
p.R18H	DO41235	UCEC	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	0.8244
p.G15E	DO41271	UCEC	ICGC	LRKFLEHLS	DEG_APCC_DBOX_1	0.7199
p.A8V	SIDM00334	Endometrial Carcinoma	GDSC	LRKFLEHLS	DEG_APCC_DBOX_1	0.1944
p.A8V	ACH-000879	Endometrial/Uterine Cancer	CCLE	LRKFLEHLS	DEG_APCC_DBOX_1	0.1944
p.G24C	ACH-000911	Gastric Cancer	CCLE	LRKFLEHLS	DEG_APCC_DBOX_1	0.25
p.A3P	ACH-001345	Colon/Colorectal Cancer	CCLE	LRKFLEHLS	DEG_APCC_DBOX_1	0.0556
p.I23V	DEL	haematopoietic_and_lymphoid_tissue	COSMIC	LRKFLEHLS	DEG_APCC_DBOX_1	0.2778
p.H25Q	GP5d	large_intestine	COSMIC	LRKFLEHLS	DEG_APCC_DBOX_1	0.6667
p.E25D	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	LRKFLEHLS	DEG_APCC_DBOX_1	0.6667
p.A16S	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	LRKFLEHLS	DEG_APCC_DBOX_1	0.7588
p.H14L	EKVX	lung	COSMIC	LRKFLEHLS	DEG_APCC_DBOX_1	0.7313
p.I23F	MCC13	skin	COSMIC	LRKFLEHLS	DEG_APCC_DBOX_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRKFLEHLS

Degron related mutations and impact score

Drug responses associated with PFKP mutations

All proteins holding degron of LRKFLEHLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01813	ATP-dependent 6-phosphofructokinase, platelet type	DEG_APCC_DBOX_1	13:21	LRKFLEHLS	APC,CDC20,FZR1	0.789	More...