DegronMD - Q02040(AKAP17A)

AKAP17A

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A424V	TCGA-AX-A1C4	UCEC	TCGA	LRERLLSIL	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.0556
p.A424V	DO42480	UCEC	ICGC	LRERLLSIL	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.0556
p.R437Q	TCGA-D1-A1O7	UCEC	TCGA	LRERLLSIL	DEG_APCC_DBOX_1	434:442	Mutation altering degron motif	0.6218
p.R437Q	DO41139	UCEC	ICGC	LRERLLSIL	DEG_APCC_DBOX_1	434:442	Mutation altering degron motif	0.6218
p.R432W	TCGA-DF-A2KU	UCEC	TCGA	LRERLLSIL	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.2778
p.R432W	DO223286	UCEC	ICGC	LRERLLSIL	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.2778
p.R446Q	DO233257	GACA	ICGC	LRERLLSIL	DEG_APCC_DBOX_1	434:442	Mutation substituting flanking lysine	0.3333
p.S450N	DO233272	GACA	ICGC	LRERLLSIL	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.1111
p.C443F	DO229018	LICA	ICGC	LRERLLSIL	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.3056
p.S445P	DO42023	UCEC	ICGC	LRERLLSIL	DEG_APCC_DBOX_1	434:442	Mutation substituting flanking lysine	0.3611
p.A424T	SIDM00928	Breast Carcinoma	GDSC	LRERLLSIL	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.0556
p.S450R	SIDM01105	Melanoma	GDSC	LRERLLSIL	DEG_APCC_DBOX_1	434:442	Mutation rewiring degron network	0.1111
p.K430N	ACH-000868	Lung Cancer	CCLE	LRERLLSIL	DEG_APCC_DBOX_1	434:442	Mutation substituting flanking lysine	0.3333
p.S440N	ACH-001669	Leukemia	CCLE	LRERLLSIL	DEG_APCC_DBOX_1	434:442	Mutation altering degron motif	0.7069

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*NOTE: the Kaplan plots were collected from OncoLnc