DegronMD

Uniprot ID: Q02040

Source protein: A-kinase anchor protein 17A

Source gene: AKAP17A

Class: DEG_APCC_DBOX_1

Location: 434:442

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6346

ASA_SCORE: 97.0111

COIL: 0.1318

CONS_SCORE: 0.4142

DSS_SCORE: 0.2971

HELIX: 0.8732

FCONS_SCORE: 1.1125

RIG_SCORE: 0.8022

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A424V	TCGA-AX-A1C4	UCEC	TCGA	LRERLLSIL	DEG_APCC_DBOX_1	0.0556
p.A424V	DO42480	UCEC	ICGC	LRERLLSIL	DEG_APCC_DBOX_1	0.0556
p.R437Q	TCGA-D1-A1O7	UCEC	TCGA	LRERLLSIL	DEG_APCC_DBOX_1	0.6218
p.R437Q	DO41139	UCEC	ICGC	LRERLLSIL	DEG_APCC_DBOX_1	0.6218
p.R432W	TCGA-DF-A2KU	UCEC	TCGA	LRERLLSIL	DEG_APCC_DBOX_1	0.2778
p.R432W	DO223286	UCEC	ICGC	LRERLLSIL	DEG_APCC_DBOX_1	0.2778
p.R446Q	DO233257	GACA	ICGC	LRERLLSIL	DEG_APCC_DBOX_1	0.3333
p.S450N	DO233272	GACA	ICGC	LRERLLSIL	DEG_APCC_DBOX_1	0.1111
p.C443F	DO229018	LICA	ICGC	LRERLLSIL	DEG_APCC_DBOX_1	0.3056
p.S445P	DO42023	UCEC	ICGC	LRERLLSIL	DEG_APCC_DBOX_1	0.3611
p.A424T	SIDM00928	Breast Carcinoma	GDSC	LRERLLSIL	DEG_APCC_DBOX_1	0.0556
p.S450R	SIDM01105	Melanoma	GDSC	LRERLLSIL	DEG_APCC_DBOX_1	0.1111
p.K430N	ACH-000868	Lung Cancer	CCLE	LRERLLSIL	DEG_APCC_DBOX_1	0.3333
p.S440N	ACH-001669	Leukemia	CCLE	LRERLLSIL	DEG_APCC_DBOX_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02040	A-kinase anchor protein 17A	DEG_APCC_DBOX_1	434:442	LRERLLSIL	APC,CDC20,FZR1	0.6346	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons