DegronMD - Q02218(OGDH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A92T	TCGA-AG-A00Y	READ	TCGA	SRGSLAAVA	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1111
p.A92T	DO36542	READ	ICGC	SRGSLAAVA	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1111
p.V114I	TCGA-B5-A3FC	UCEC	TCGA	SRGSLAAVA	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1667
p.V114I	DO41871	UCEC	ICGC	SRGSLAAVA	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1667
p.V107L	TCGA-BQ-7059	KIRP	TCGA	SRGSLAAVA	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.5654
p.V107L	DO20932	KIRP	ICGC	SRGSLAAVA	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.5654
p.H109Y	TCGA-D3-A8GM	SKCM	TCGA	SRGSLAAVA	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.3056
p.H109Y	DO50288	SKCM	ICGC	SRGSLAAVA	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.3056
p.P98S	TCGA-EE-A2MS	SKCM	TCGA	SRGSLAAVA	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.2778
p.P98S	DO37567	SKCM	ICGC	SRGSLAAVA	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.2778
p.A108T	TCGA-EY-A1GI	UCEC	TCGA	SRGSLAAVA	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.6028
p.A108T	DO41211	UCEC	ICGC	SRGSLAAVA	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.6028
p.L104V	TCGA-UF-A7JF	HNSC	TCGA	SRGSLAAVA	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.6765
p.L104V	DO52116	HNSC	ICGC	SRGSLAAVA	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.6765
p.Y93H	DO222643	BTCA	ICGC	SRGSLAAVA	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1389
p.G111C	DO234320	ESAD	ICGC	SRGSLAAVA	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.25
p.A116G	DO233694	GACA	ICGC	SRGSLAAVA	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1111
p.S95I	DO233935	GACA	ICGC	SRGSLAAVA	DEG_APCC_DBOX_1	100:108	Mutation blocking phosphorylation signal	0.6389
p.A106V	SIDM01196	Hepatocellular Carcinoma	GDSC	SRGSLAAVA	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.5825
p.A106V	ACH-000422	Liver Cancer	CCLE	SRGSLAAVA	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.5825
p.A106V	SNU-475	liver	COSMIC	SRGSLAAVA	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.5825
p.D98G	HT	haematopoietic and lymphoid tissue	COSMIC	SRGSLAAVA	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.2778
p.F117L	NCI-H1563	lung	COSMIC	SRGSLAAVA	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.0833

Kaplan plot for OGDH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OGDH

UniProt ID: Q02218

Entrez ID: 4967

Protein name: 2-oxoglutarate dehydrogenase complex component E1 (E1o) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OGDH in