DegronMD

Uniprot ID: Q02218

Source protein: 2-oxoglutarate dehydrogenase complex component E1

Source gene: OGDH

Class: DEG_APCC_DBOX_1

Location: 100:108

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6731

ASA_SCORE: 64.8667

COIL: 0.4748

CONS_SCORE: 0.2128

DSS_SCORE: 0.2869

HELIX: 0.5071

FCONS_SCORE: 0.7839

RIG_SCORE: 0.703

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A92T	TCGA-AG-A00Y	READ	TCGA	SRGSLAAVA	DEG_APCC_DBOX_1	0.1111
p.A92T	DO36542	READ	ICGC	SRGSLAAVA	DEG_APCC_DBOX_1	0.1111
p.V114I	TCGA-B5-A3FC	UCEC	TCGA	SRGSLAAVA	DEG_APCC_DBOX_1	0.1667
p.V114I	DO41871	UCEC	ICGC	SRGSLAAVA	DEG_APCC_DBOX_1	0.1667
p.V107L	TCGA-BQ-7059	KIRP	TCGA	SRGSLAAVA	DEG_APCC_DBOX_1	0.5654
p.V107L	DO20932	KIRP	ICGC	SRGSLAAVA	DEG_APCC_DBOX_1	0.5654
p.H109Y	TCGA-D3-A8GM	SKCM	TCGA	SRGSLAAVA	DEG_APCC_DBOX_1	0.3056
p.H109Y	DO50288	SKCM	ICGC	SRGSLAAVA	DEG_APCC_DBOX_1	0.3056
p.P98S	TCGA-EE-A2MS	SKCM	TCGA	SRGSLAAVA	DEG_APCC_DBOX_1	0.2778
p.P98S	DO37567	SKCM	ICGC	SRGSLAAVA	DEG_APCC_DBOX_1	0.2778
p.A108T	TCGA-EY-A1GI	UCEC	TCGA	SRGSLAAVA	DEG_APCC_DBOX_1	0.6028
p.A108T	DO41211	UCEC	ICGC	SRGSLAAVA	DEG_APCC_DBOX_1	0.6028
p.L104V	TCGA-UF-A7JF	HNSC	TCGA	SRGSLAAVA	DEG_APCC_DBOX_1	0.6765
p.L104V	DO52116	HNSC	ICGC	SRGSLAAVA	DEG_APCC_DBOX_1	0.6765
p.Y93H	DO222643	BTCA	ICGC	SRGSLAAVA	DEG_APCC_DBOX_1	0.1389
p.G111C	DO234320	ESAD	ICGC	SRGSLAAVA	DEG_APCC_DBOX_1	0.25
p.A116G	DO233694	GACA	ICGC	SRGSLAAVA	DEG_APCC_DBOX_1	0.1111
p.S95I	DO233935	GACA	ICGC	SRGSLAAVA	DEG_APCC_DBOX_1	0.6389
p.A106V	SIDM01196	Hepatocellular Carcinoma	GDSC	SRGSLAAVA	DEG_APCC_DBOX_1	0.5825
p.A106V	ACH-000422	Liver Cancer	CCLE	SRGSLAAVA	DEG_APCC_DBOX_1	0.5825
p.A106V	SNU-475	liver	COSMIC	SRGSLAAVA	DEG_APCC_DBOX_1	0.5825
p.D98G	HT	haematopoietic_and_lymphoid_tissue	COSMIC	SRGSLAAVA	DEG_APCC_DBOX_1	0.2778
p.F117L	NCI-H1563	lung	COSMIC	SRGSLAAVA	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02218	2-oxoglutarate dehydrogenase complex component E1	DEG_APCC_DBOX_1	100:108	SRGSLAAVA	APC,CDC20,FZR1	0.6731	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons