NRG1
UniProt ID: Q02297
Entrez ID: 3084
Protein name: Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)]
External links: UniprotKB HGNC RefSeq COSMIC
Please click HERE
for better display.
FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differe...
FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity). {ECO:0000250|UniProtKB:P43322, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:1348215, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:7902537}.
View more >>
GO - Biological processes (BP):
activation of protein kinase B activity [GO:0032148]; activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; animal organ development [GO:0048513]; cardiac conduction system development [GO:0003161]; cardiac muscle cell differentiation [GO:0055007]; cardiac muscle cell m...
activation of protein kinase B activity [GO:0032148]; activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; animal organ development [GO:0048513]; cardiac conduction system development [GO:0003161]; cardiac muscle cell differentiation [GO:0055007]; cardiac muscle cell myoblast differentiation [GO:0060379]; cell communication [GO:0007154]; cell differentiation [GO:0030154]; cell morphogenesis [GO:0000902]; cell population proliferation [GO:0008283]; chemorepulsion involved in interneuron migration from the subpallium to the cortex [GO:0021842]; endocardial cell differentiation [GO:0060956]; ERBB3 signaling pathway [GO:0038129]; ERBB4-ERBB4 signaling pathway [GO:0038138]; ERBB4 signaling pathway [GO:0038130]; ERBB signaling pathway [GO:0038127]; glial cell fate commitment [GO:0021781]; intracellular signal transduction [GO:0035556]; locomotory behavior [GO:0007626]; mammary gland development [GO:0030879]; MAPK cascade [GO:0000165]; myelination in peripheral nervous system [GO:0022011]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of neuron migration [GO:2001223]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of secretion [GO:0051048]; negative regulation of transcription, DNA-templated [GO:0045892]; nervous system development [GO:0007399]; neural crest cell development [GO:0014032]; neuron fate commitment [GO:0048663]; neurotransmitter receptor metabolic process [GO:0045213]; oligodendrocyte differentiation [GO:0048709]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-tyrosine autophosphorylation [GO:1900086]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of striated muscle cell differentiation [GO:0051155]; postsynapse to nucleus signaling pathway [GO:0099527]; protein-containing complex disassembly [GO:0032984]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; synapse assembly [GO:0007416]; synaptic membrane adhesion [GO:0099560]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; ventricular cardiac muscle cell differentiation [GO:0055012]; ventricular trabecula myocardium morphogenesis [GO:0003222]; wound healing [GO:0042060]
View more >>
GO - Molecular function (MF):
chemorepellent activity [GO:0045499]; cytokine activity [GO:0005125]; ErbB-2 class receptor binding [GO:0005176]; ErbB-3 class receptor binding [GO:0043125]; growth factor activity [GO:0008083]; integrin binding [GO:0005178]; protein tyrosine kinase activator activity [GO:0030296]; receptor ligand a...
chemorepellent activity [GO:0045499]; cytokine activity [GO:0005125]; ErbB-2 class receptor binding [GO:0005176]; ErbB-3 class receptor binding [GO:0043125]; growth factor activity [GO:0008083]; integrin binding [GO:0005178]; protein tyrosine kinase activator activity [GO:0030296]; receptor ligand activity [GO:0048018]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102]; transcription coregulator activity [GO:0003712]; transmembrane receptor protein tyrosine kinase activator activity [GO:0030297]
View more >>
GO - Cellular component (CC):
apical plasma membrane [GO:0016324]; axon [GO:0030424]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; integral component of plasma membrane [GO:0005887]; integral component of postsyna...
apical plasma membrane [GO:0016324]; axon [GO:0030424]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; integral component of plasma membrane [GO:0005887]; integral component of postsynaptic density membrane [GO:0099061]; integral component of presynaptic active zone membrane [GO:0099059]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]
View more >>
NRG1
Control panel
Show dataset:
Show Degron:
All sites
Degron
Degron
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for NRG1 in
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc