DegronMD

Uniprot ID: Q02297

Source protein: Pro-neuregulin-1, membrane-bound isoform

Source gene: NRG1

Class: DEG_SCF_FBW7_1

Location: 347:354

E3 ligase: FBXW7

DEGRON score: 0.9553

ASA_SCORE: 81.15

COIL: 0.8555

CONS_SCORE: 0.8264

DSS_SCORE: 0.5777

HELIX: 0.0658

FCONS_SCORE: 0.9563

RIG_SCORE: 0.6581

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S338P	TCGA-AZ-4315	COAD	TCGA	VTQTPSHS	DEG_SCF_FBW7_1	0.0833
p.Q354H	TCGA-N7-A4Y8	UCS	TCGA	VTQTPSHS	DEG_SCF_FBW7_1	0.7582
p.S338F	TCGA-WE-A8JZ	SKCM	TCGA	VTQTPSHS	DEG_SCF_FBW7_1	0.0833
p.S338F	TCGA-YD-A9TB	SKCM	TCGA	VTQTPSHS	DEG_SCF_FBW7_1	0.0833
p.H357R	DO10340	COAD	ICGC	VTQTPSHS	DEG_SCF_FBW7_1	0.25
p.N352T	DO8914	COAD	ICGC	VTQTPSHS	DEG_SCF_FBW7_1	0.7055
p.L342P	DO222755	COCA	ICGC	VTQTPSHS	DEG_SCF_FBW7_1	0.1944
p.L342P	DO50402	ESAD	ICGC	VTQTPSHS	DEG_SCF_FBW7_1	0.1944
p.L342P	DO234212	ESAD	ICGC	VTQTPSHS	DEG_SCF_FBW7_1	0.1944
p.L342P	DO10858	ESAD	ICGC	VTQTPSHS	DEG_SCF_FBW7_1	0.1944
p.L342P	DO233718	GACA	ICGC	VTQTPSHS	DEG_SCF_FBW7_1	0.1944
p.R359G	DO233151	GACA	ICGC	VTQTPSHS	DEG_SCF_FBW7_1	0.1944
p.R359G	DO233705	GACA	ICGC	VTQTPSHS	DEG_SCF_FBW7_1	0.1944
p.G344C	DO228971	LICA	ICGC	VTQTPSHS	DEG_SCF_FBW7_1	0.25
p.G340V	DO229035	LICA	ICGC	VTQTPSHS	DEG_SCF_FBW7_1	0.1389
p.S364F	DO220899	MELA	ICGC	VTQTPSHS	DEG_SCF_FBW7_1	0.0556
p.R341S	DO227579	ORCA	ICGC	VTQTPSHS	DEG_SCF_FBW7_1	0.1667
p.N343D	DO232761	PBCA	ICGC	VTQTPSHS	DEG_SCF_FBW7_1	0.2222
p.D363N	DO37707	SKCM	ICGC	VTQTPSHS	DEG_SCF_FBW7_1	0.0833
p.R349C	DO43755	UCEC	ICGC	VTQTPSHS	DEG_SCF_FBW7_1	0.8301
p.E360K	DO41331	UCEC	ICGC	VTQTPSHS	DEG_SCF_FBW7_1	0.1667
p.L342F	DO41379	UCEC	ICGC	VTQTPSHS	DEG_SCF_FBW7_1	0.1944
p.S353G	HEC-1	endometrium	COSMIC	VTQTPSHS	DEG_SCF_FBW7_1	0.6993
p.R339K	CP67-MEL	skin	COSMIC	VTQTPSHS	DEG_SCF_FBW7_1	0.1111
p.T361A	LoVo	large_intestine	COSMIC	VTQTPSHS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02297	Pro-neuregulin-1, membrane-bound isoform	DEG_SCF_FBW7_1	347:354	VTQTPSHS	FBXW7	0.9553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons