DegronMD - Q02487(DSC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P473H	TCGA-3R-A8YX	SARC	TCGA	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.1389
p.P473H	DO219943	SARC	ICGC	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.1389
p.P473T	TCGA-49-6742	LUAD	TCGA	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.1389
p.P473T	DO25622	LUAD	ICGC	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.1389
p.R479H	TCGA-A8-A07L	BRCA	TCGA	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.3056
p.R479H	TCGA-CM-4746	COAD	TCGA	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.3056
p.R479H	DO2377	BRCA	ICGC	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.3056
p.R479H	DO7882	COAD	ICGC	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.3056
p.R479H	DO233709	GACA	ICGC	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.3056
p.P474A	TCGA-B3-4104	KIRP	TCGA	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.1667
p.M480I	TCGA-D3-A8GM	SKCM	TCGA	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation altering degron motif	0.6507
p.M480I	TCGA-QB-A6FS	SKCM	TCGA	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation altering degron motif	0.6507
p.M480I	DO50288	SKCM	ICGC	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation altering degron motif	0.6507
p.M480I	DO48654	SKCM	ICGC	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation altering degron motif	0.6507
p.E485K	TCGA-EE-A20H	SKCM	TCGA	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.3056
p.E485K	DO37986	SKCM	ICGC	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.3056
p.G487R	TCGA-EO-A3KX	UCEC	TCGA	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.25
p.G487R	DO219774	UCEC	ICGC	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.25
p.G487E	TCGA-FW-A3R5	SKCM	TCGA	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.25
p.G487E	DO222418	MELA	ICGC	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.25
p.G487E	DO37406	SKCM	ICGC	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.25
p.R479C	TCGA-W3-AA1V	SKCM	TCGA	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.3056
p.R479C	DO222363	MELA	ICGC	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.3056
p.R479C	DO51276	SKCM	ICGC	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.3056
p.E482G	ACH-000419	Myeloma	CCLE	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation altering degron motif	0.7199
p.C471Y	ACH-001807	Liposarcoma	CCLE	MKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.0833

Kaplan plot for DSC2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DSC2

UniProt ID: Q02487

Entrez ID: 1824

Protein name: Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DSC2 in