DegronMD

Uniprot ID: Q02487

Source protein: Desmocollin-2

Source gene: DSC2

Class: DEG_APCC_KENBOX_2

Location: 480:484

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8458

ASA_SCORE: 57.3

COIL: 0.6314

CONS_SCORE: 0.5759

DSS_SCORE: 0.5728

HELIX: 0.0228

FCONS_SCORE: 1.0052

RIG_SCORE: 0.7442

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P473H	TCGA-3R-A8YX	SARC	TCGA	MKENA	DEG_APCC_KENBOX_2	0.1389
p.P473H	DO219943	SARC	ICGC	MKENA	DEG_APCC_KENBOX_2	0.1389
p.P473T	TCGA-49-6742	LUAD	TCGA	MKENA	DEG_APCC_KENBOX_2	0.1389
p.P473T	DO25622	LUAD	ICGC	MKENA	DEG_APCC_KENBOX_2	0.1389
p.R479H	TCGA-A8-A07L	BRCA	TCGA	MKENA	DEG_APCC_KENBOX_2	0.3056
p.R479H	TCGA-CM-4746	COAD	TCGA	MKENA	DEG_APCC_KENBOX_2	0.3056
p.R479H	DO2377	BRCA	ICGC	MKENA	DEG_APCC_KENBOX_2	0.3056
p.R479H	DO7882	COAD	ICGC	MKENA	DEG_APCC_KENBOX_2	0.3056
p.R479H	DO233709	GACA	ICGC	MKENA	DEG_APCC_KENBOX_2	0.3056
p.P474A	TCGA-B3-4104	KIRP	TCGA	MKENA	DEG_APCC_KENBOX_2	0.1667
p.M480I	TCGA-D3-A8GM	SKCM	TCGA	MKENA	DEG_APCC_KENBOX_2	0.6507
p.M480I	TCGA-QB-A6FS	SKCM	TCGA	MKENA	DEG_APCC_KENBOX_2	0.6507
p.M480I	DO50288	SKCM	ICGC	MKENA	DEG_APCC_KENBOX_2	0.6507
p.M480I	DO48654	SKCM	ICGC	MKENA	DEG_APCC_KENBOX_2	0.6507
p.E485K	TCGA-EE-A20H	SKCM	TCGA	MKENA	DEG_APCC_KENBOX_2	0.3056
p.E485K	DO37986	SKCM	ICGC	MKENA	DEG_APCC_KENBOX_2	0.3056
p.G487R	TCGA-EO-A3KX	UCEC	TCGA	MKENA	DEG_APCC_KENBOX_2	0.25
p.G487R	DO219774	UCEC	ICGC	MKENA	DEG_APCC_KENBOX_2	0.25
p.G487E	TCGA-FW-A3R5	SKCM	TCGA	MKENA	DEG_APCC_KENBOX_2	0.25
p.G487E	DO222418	MELA	ICGC	MKENA	DEG_APCC_KENBOX_2	0.25
p.G487E	DO37406	SKCM	ICGC	MKENA	DEG_APCC_KENBOX_2	0.25
p.R479C	TCGA-W3-AA1V	SKCM	TCGA	MKENA	DEG_APCC_KENBOX_2	0.3056
p.R479C	DO222363	MELA	ICGC	MKENA	DEG_APCC_KENBOX_2	0.3056
p.R479C	DO51276	SKCM	ICGC	MKENA	DEG_APCC_KENBOX_2	0.3056
p.E482G	ACH-000419	Myeloma	CCLE	MKENA	DEG_APCC_KENBOX_2	0.7199
p.C471Y	ACH-001807	Liposarcoma	CCLE	MKENA	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02487	Desmocollin-2	DEG_APCC_KENBOX_2	480:484	MKENA	APC,CDC20,FZR1	0.8458	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons