DegronMD - Q02509(OC90)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E201K	TCGA-05-4422	LUAD	TCGA	LAQTPETT	DEG_SCF_FBW7_1	191:198	Mutation rewiring degron network	0.25
p.E201K	DO25907	LUAD	ICGC	LAQTPETT	DEG_SCF_FBW7_1	191:198	Mutation rewiring degron network	0.25
p.R463P	TCGA-22-5483	LUSC	TCGA	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.7512
p.R463P	DO26614	LUSC	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.7512
p.R460K	TCGA-A5-A0G2	UCEC	TCGA	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.2778
p.R460K	DO41235	UCEC	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.2778
p.L455I	TCGA-AP-A056	UCEC	TCGA	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.1389
p.L455I	DO43971	UCEC	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.1389
p.D454G	TCGA-AP-A056	UCEC	TCGA	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.1111
p.D454G	DO43971	UCEC	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.1111
p.G472R	TCGA-AX-A0J1	UCEC	TCGA	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.2778
p.G472R	DO41199	UCEC	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.2778
p.E453K	TCGA-BF-AAP2	SKCM	TCGA	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.0833
p.E453K	DO219466	SKCM	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.0833
p.G470W	TCGA-CR-7364	HNSC	TCGA	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.6714
p.G470W	DO15679	HNSC	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.6714
p.L203F	TCGA-CV-5444	HNSC	TCGA	LAQTPETT	DEG_SCF_FBW7_1	191:198	Mutation rewiring degron network	0.1944
p.L203F	DO14598	HNSC	ICGC	LAQTPETT	DEG_SCF_FBW7_1	191:198	Mutation rewiring degron network	0.1944
p.S465L	TCGA-EE-A29E	SKCM	TCGA	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.6556
p.S465L	DO37831	SKCM	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.6556
p.A458T	TCGA-EE-A29E	SKCM	TCGA	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.2222
p.A458T	DO37831	SKCM	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.2222
p.R457I	TCGA-EO-A22R	UCEC	TCGA	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.1944
p.R457I	DO42713	UCEC	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.1944
p.P468L	TCGA-FR-A726	SKCM	TCGA	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.6471
p.P468L	DO48665	SKCM	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.6471
p.D202V	TCGA-FW-A3R5	SKCM	TCGA	LAQTPETT	DEG_SCF_FBW7_1	191:198	Mutation rewiring degron network	0.2222
p.D202V	DO37406	SKCM	ICGC	LAQTPETT	DEG_SCF_FBW7_1	191:198	Mutation rewiring degron network	0.2222
p.D202N	TCGA-FW-A3R5	SKCM	TCGA	LAQTPETT	DEG_SCF_FBW7_1	191:198	Mutation rewiring degron network	0.2222
p.D202N	DO37406	SKCM	ICGC	LAQTPETT	DEG_SCF_FBW7_1	191:198	Mutation rewiring degron network	0.2222
p.L207V	TCGA-JW-A5VL	CESC	TCGA	LAQTPETT	DEG_SCF_FBW7_1	191:198	Mutation rewiring degron network	0.0833
p.L207V	DO49976	CESC	ICGC	LAQTPETT	DEG_SCF_FBW7_1	191:198	Mutation rewiring degron network	0.0833
p.A199P	DO48367	BLCA	ICGC	LAQTPETT	DEG_SCF_FBW7_1	191:198	Mutation rewiring degron network	0.3056
p.E463K	DO6296	CESC	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.7022
p.E463K	DO26444	LUSC	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.7022
p.E463K	DO51301	SKCM	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.7022
p.E463K	DO38292	STAD	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.7022
p.A476D	DO8618	COAD	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.1667
p.K200T	DO234269	ESAD	ICGC	LAQTPETT	DEG_SCF_FBW7_1	191:198	Mutation rewiring degron network	0.2778
p.T204P	DO234426	ESAD	ICGC	LAQTPETT	DEG_SCF_FBW7_1	191:198	Mutation rewiring degron network	0.1667
p.L184I	DO48211	ESCA	ICGC	LAQTPETT	DEG_SCF_FBW7_1	191:198	Mutation rewiring degron network	0.1389
p.G472S	DO233203	GACA	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.2778
p.G456S	DO233203	GACA	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.1667
p.R463W	DO233624	GACA	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.8634
p.R479W	DO233624	GACA	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.0833
p.T187N	DO229018	LICA	ICGC	LAQTPETT	DEG_SCF_FBW7_1	191:198	Mutation rewiring degron network	0.2222
p.A458D	DO229031	LICA	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.2222
p.A458D	DO229035	LICA	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.2222
p.Q468K	DO229008	LICA	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.6944
p.Q452K	DO229008	LICA	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.0556
p.G477D	DO50970	LICA	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.1389
p.A463E	DO231590	LINC	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.7701
p.V466I	DO231691	LINC	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.7076
p.T203I	DO230530	LUSC	ICGC	LAQTPETT	DEG_SCF_FBW7_1	191:198	Mutation rewiring degron network	0.1944
p.S458Y	DO26886	LUSC	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.2222
p.P475S	DO26444	LUSC	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.1944
p.P475S	DO50301	SKCM	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.1944
p.G455S	DO26444	LUSC	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.1389
p.D454N	DO220851	MELA	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.1111
p.D470N	DO220851	MELA	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.6932
p.E460K	DO220912	MELA	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.2778
p.P467L	DO35597	PBCA	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.7582
p.A476V	DO219936	SARC	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.1667
p.A474T	DO37831	SKCM	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.2222
p.P467Q	DO47284	SKCM	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.7035
p.S480F	DO37806	SKCM	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.0556
p.P456L	DO47700	SKCM	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.1667
p.Q193R	DO229259	THCA	ICGC	LAQTPETT	DEG_SCF_FBW7_1	191:198	Mutation altering degron motif	0.6218
p.S194Y	DO41020	UCEC	ICGC	LAQTPETT	DEG_SCF_FBW7_1	191:198	Mutation altering degron motif	0.712
p.L471I	DO43971	UCEC	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.3056
p.D470G	DO43971	UCEC	ICGC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.7198
p.K464T	SIDM01307	Colorectal Carcinoma	GDSC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation altering degron motif	0.6195
p.P473T	SIDM00656	Burkitt's Lymphoma	GDSC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.25
p.P473T	SIDM00641	Burkitt's Lymphoma	GDSC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.25
p.G456D	SIDM01120	Other Solid Cancers	GDSC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.1667
p.G456D	ACH-002174	Lung Cancer	CCLE	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.1667
p.G456D	NCI-H720	lung	COSMIC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.1667
p.A458G	SIDM00485	Oral Cavity Carcinoma	GDSC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.2222
p.A458G	ACH-000794	Head and Neck Cancer	CCLE	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.2222
p.A458G	BICR22	upper aerodigestive tract	COSMIC	LRKSLGPLG	DEG_APCC_DBOX_1	462:470	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OC90

UniProt ID: Q02509

Entrez ID: 729330

Protein name: Otoconin-90 (Oc90) (Phospholipase A2 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for OC90 in