DegronMD

Uniprot ID: Q02509

Source protein: Otoconin-90

Source gene: OC90

Class: DEG_SCF_FBW7_1

Location: 191:198

E3 ligase: FBXW7

DEGRON score: 0.7265

ASA_SCORE: 78.6125

COIL: 0.7678

CONS_SCORE: 0.5791

DSS_SCORE: 0.2071

HELIX: 0.1076

FCONS_SCORE: 1.097

RIG_SCORE: 0.7859

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E201K	TCGA-05-4422	LUAD	TCGA	LAQTPETT	DEG_SCF_FBW7_1	0.25
p.E201K	DO25907	LUAD	ICGC	LAQTPETT	DEG_SCF_FBW7_1	0.25
p.L203F	TCGA-CV-5444	HNSC	TCGA	LAQTPETT	DEG_SCF_FBW7_1	0.1944
p.L203F	DO14598	HNSC	ICGC	LAQTPETT	DEG_SCF_FBW7_1	0.1944
p.D202V	TCGA-FW-A3R5	SKCM	TCGA	LAQTPETT	DEG_SCF_FBW7_1	0.2222
p.D202V	DO37406	SKCM	ICGC	LAQTPETT	DEG_SCF_FBW7_1	0.2222
p.D202N	TCGA-FW-A3R5	SKCM	TCGA	LAQTPETT	DEG_SCF_FBW7_1	0.2222
p.D202N	DO37406	SKCM	ICGC	LAQTPETT	DEG_SCF_FBW7_1	0.2222
p.L207V	TCGA-JW-A5VL	CESC	TCGA	LAQTPETT	DEG_SCF_FBW7_1	0.0833
p.L207V	DO49976	CESC	ICGC	LAQTPETT	DEG_SCF_FBW7_1	0.0833
p.A199P	DO48367	BLCA	ICGC	LAQTPETT	DEG_SCF_FBW7_1	0.3056
p.K200T	DO234269	ESAD	ICGC	LAQTPETT	DEG_SCF_FBW7_1	0.2778
p.T204P	DO234426	ESAD	ICGC	LAQTPETT	DEG_SCF_FBW7_1	0.1667
p.L184I	DO48211	ESCA	ICGC	LAQTPETT	DEG_SCF_FBW7_1	0.1389
p.T187N	DO229018	LICA	ICGC	LAQTPETT	DEG_SCF_FBW7_1	0.2222
p.T203I	DO230530	LUSC	ICGC	LAQTPETT	DEG_SCF_FBW7_1	0.1944
p.Q193R	DO229259	THCA	ICGC	LAQTPETT	DEG_SCF_FBW7_1	0.6218
p.S194Y	DO41020	UCEC	ICGC	LAQTPETT	DEG_SCF_FBW7_1	0.712

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02509	Otoconin-90	DEG_SCF_FBW7_1	191:198	LAQTPETT	FBXW7	0.7265	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons