DegronMD - Q02575(NHLH1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R55Q	TCGA-A6-6781	COAD	TCGA	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation altering degron motif	0.7329
p.R55Q	DO8447	COAD	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation altering degron motif	0.7329
p.R55Q	DO222908	MELA	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation altering degron motif	0.7329
p.A72T	TCGA-AC-A62V	BRCA	TCGA	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.A72T	TCGA-AJ-A3BH	UCEC	TCGA	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.A72T	TCGA-B5-A3FC	UCEC	TCGA	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.A72T	TCGA-EV-5901	KIRP	TCGA	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.A72T	DO50024	BRCA	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.A72T	DO20802	KIRP	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.A72T	DO41638	UCEC	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.A72T	DO41871	UCEC	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.R66C	TCGA-BS-A0TA	UCEC	TCGA	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.2222
p.R66C	TCGA-R5-A804	STAD	TCGA	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.2222
p.R66C	DO222344	STAD	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.2222
p.R66C	DO43298	UCEC	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.2222
p.R63C	TCGA-BS-A0VI	UCEC	TCGA	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.3056
p.R63C	DO41764	UCEC	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.3056
p.R69W	TCGA-D6-6516	HNSC	TCGA	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.1389
p.R69W	DO233203	GACA	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.1389
p.R69W	DO15623	HNSC	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.1389
p.P53H	DO230309	COCA	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.3056
p.R69Q	DO233030	GACA	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.1389
p.R69Q	DO233762	GACA	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.1389
p.R69Q	DO49466	PACA	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.1389
p.R69Q	SIDM01943	Colorectal Carcinoma	GDSC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.1389
p.R69Q	ACH-001982	Metastasis	CCLE	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.1389
p.A45S	DO233210	GACA	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0833
p.R63H	DO233676	GACA	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.3056
p.R71C	DO45183	LIRI	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0833
p.R46Q	DO224610	LUSC	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.1111
p.R46Q	ACH-000779	Lung Cancer	CCLE	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.1111
p.R67Q	SIDM00014	Colorectal Carcinoma	GDSC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.1944
p.R67Q	LIM1215	large intestine	COSMIC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.1944
p.Q59H	SIDM00214	Colorectal Carcinoma	GDSC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation altering degron motif	0.647
p.Q59H	ACH-000955	Colon/Colorectal Cancer	CCLE	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation altering degron motif	0.647
p.Q59H	SNU-407	large intestine	COSMIC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation altering degron motif	0.647
p.P50Q	ACH-000137	Brain Cancer	CCLE	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.2222
p.P50Q	8-MG-BA	central nervous system	COSMIC	GRKDLQHLS	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.2222

Kaplan plot for NHLH1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NHLH1

UniProt ID: Q02575

Entrez ID: 4807

Protein name: Helix-loop-helix protein 1 (HEN-1) (Class A basic helix-loop-helix protein 35) (bHLHa35) (Nescient helix loop helix 1) (NSCL-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NHLH1 in