DegronMD

Uniprot ID: Q02575

Source protein: Helix-loop-helix protein 1

Source gene: NHLH1

Class: DEG_APCC_DBOX_1

Location: 54:62

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6536

ASA_SCORE: 102.8667

COIL: 0.7178

CONS_SCORE: 0.5842

DSS_SCORE: 0.8021

HELIX: 0.2737

FCONS_SCORE: 0.8725

RIG_SCORE: 0.6532

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R55Q	TCGA-A6-6781	COAD	TCGA	GRKDLQHLS	DEG_APCC_DBOX_1	0.7329
p.R55Q	DO8447	COAD	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	0.7329
p.R55Q	DO222908	MELA	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	0.7329
p.A72T	TCGA-AC-A62V	BRCA	TCGA	GRKDLQHLS	DEG_APCC_DBOX_1	0.0556
p.A72T	TCGA-AJ-A3BH	UCEC	TCGA	GRKDLQHLS	DEG_APCC_DBOX_1	0.0556
p.A72T	TCGA-B5-A3FC	UCEC	TCGA	GRKDLQHLS	DEG_APCC_DBOX_1	0.0556
p.A72T	TCGA-EV-5901	KIRP	TCGA	GRKDLQHLS	DEG_APCC_DBOX_1	0.0556
p.A72T	DO50024	BRCA	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	0.0556
p.A72T	DO20802	KIRP	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	0.0556
p.A72T	DO41638	UCEC	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	0.0556
p.A72T	DO41871	UCEC	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	0.0556
p.R66C	TCGA-BS-A0TA	UCEC	TCGA	GRKDLQHLS	DEG_APCC_DBOX_1	0.2222
p.R66C	TCGA-R5-A804	STAD	TCGA	GRKDLQHLS	DEG_APCC_DBOX_1	0.2222
p.R66C	DO222344	STAD	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	0.2222
p.R66C	DO43298	UCEC	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	0.2222
p.R63C	TCGA-BS-A0VI	UCEC	TCGA	GRKDLQHLS	DEG_APCC_DBOX_1	0.3056
p.R63C	DO41764	UCEC	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	0.3056
p.R69W	TCGA-D6-6516	HNSC	TCGA	GRKDLQHLS	DEG_APCC_DBOX_1	0.1389
p.R69W	DO233203	GACA	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	0.1389
p.R69W	DO15623	HNSC	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	0.1389
p.P53H	DO230309	COCA	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	0.3056
p.R69Q	DO233030	GACA	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	0.1389
p.R69Q	DO233762	GACA	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	0.1389
p.R69Q	DO49466	PACA	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	0.1389
p.R69Q	SIDM01943	Colorectal Carcinoma	GDSC	GRKDLQHLS	DEG_APCC_DBOX_1	0.1389
p.R69Q	ACH-001982	Metastasis	CCLE	GRKDLQHLS	DEG_APCC_DBOX_1	0.1389
p.A45S	DO233210	GACA	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	0.0833
p.R63H	DO233676	GACA	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	0.3056
p.R71C	DO45183	LIRI	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	0.0833
p.R46Q	DO224610	LUSC	ICGC	GRKDLQHLS	DEG_APCC_DBOX_1	0.1111
p.R46Q	ACH-000779	Lung Cancer	CCLE	GRKDLQHLS	DEG_APCC_DBOX_1	0.1111
p.R67Q	SIDM00014	Colorectal Carcinoma	GDSC	GRKDLQHLS	DEG_APCC_DBOX_1	0.1944
p.R67Q	LIM1215	large_intestine	COSMIC	GRKDLQHLS	DEG_APCC_DBOX_1	0.1944
p.Q59H	SIDM00214	Colorectal Carcinoma	GDSC	GRKDLQHLS	DEG_APCC_DBOX_1	0.647
p.Q59H	ACH-000955	Colon/Colorectal Cancer	CCLE	GRKDLQHLS	DEG_APCC_DBOX_1	0.647
p.Q59H	SNU-407	large_intestine	COSMIC	GRKDLQHLS	DEG_APCC_DBOX_1	0.647
p.P50Q	ACH-000137	Brain Cancer	CCLE	GRKDLQHLS	DEG_APCC_DBOX_1	0.2222
p.P50Q	8-MG-BA	central_nervous_system	COSMIC	GRKDLQHLS	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRKDLQHLS

Degron related mutations and impact score

Drug responses associated with NHLH1 mutations

All proteins holding degron of GRKDLQHLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02575	Helix-loop-helix protein 1	DEG_APCC_DBOX_1	54:62	GRKDLQHLS	APC,CDC20,FZR1	0.6536	More...