DegronMD - Q02779(MAP3K10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P781L	TCGA-DA-A3F8	SKCM	TCGA	PAPTPTPS	DEG_SCF_FBW7_1	781:788	Mutation altering degron motif	0.6471
p.P781L	DO37418	SKCM	ICGC	PAPTPTPS	DEG_SCF_FBW7_1	781:788	Mutation altering degron motif	0.6471
p.A772T	DO23122	LINC	ICGC	PAPTPTPS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.0833
p.A772T	ACH-001982	Metastasis	CCLE	PAPTPTPS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.0833
p.T786M	DO23448	LINC	ICGC	PAPTPTPS	DEG_SCF_FBW7_1	781:788	Mutation altering degron motif	0.6312
p.S779P	DO229208	THCA	ICGC	PAPTPTPS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.2778
p.S779P	DO229218	THCA	ICGC	PAPTPTPS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.2778
p.S779P	DO229211	THCA	ICGC	PAPTPTPS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.2778
p.S779P	DO229229	THCA	ICGC	PAPTPTPS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.2778
p.S779P	DO229245	THCA	ICGC	PAPTPTPS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.2778
p.T784K	DO229208	THCA	ICGC	PAPTPTPS	DEG_SCF_FBW7_1	781:788	Mutation altering degron motif	0.7306
p.P780L	DO229542	UTCA	ICGC	PAPTPTPS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.3056
p.S779F	SIDM01175	Other Sarcomas	GDSC	PAPTPTPS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.2778
p.S779F	SIDM00333	Endometrial Carcinoma	GDSC	PAPTPTPS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.2778
p.S779F	ACH-000988	Endometrial/Uterine Cancer	CCLE	PAPTPTPS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.2778
p.A772G	SIDM00552	Rhabdomyosarcoma	GDSC	PAPTPTPS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.0833
p.A772G	SIDM01685	B-Lymphoblastic Leukemia	GDSC	PAPTPTPS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.0833
p.A772G	SIDM01619	Endometrial Carcinoma	GDSC	PAPTPTPS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.0833
p.A772G	KYM-1	soft tissue	COSMIC	PAPTPTPS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.0833
p.P783L	ACH-000947	Ovarian Cancer	CCLE	PAPTPTPS	DEG_SCF_FBW7_1	781:788	Mutation altering degron motif	0.6471
p.A782T	ACH-000954	Endometrial/Uterine Cancer	CCLE	PAPTPTPS	DEG_SCF_FBW7_1	781:788	Mutation altering degron motif	0.6028
p.T786A	ACH-001719	Ovarian Cancer	CCLE	PAPTPTPS	DEG_SCF_FBW7_1	781:788	Mutation altering degron motif	0.6028

Kaplan plot for MAP3K10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP3K10

UniProt ID: Q02779

Entrez ID: 4294

Protein name: Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAP3K10 in