DegronMD

Uniprot ID: Q02779

Source protein: Mitogen-activated protein kinase kinase kinase 10

Source gene: MAP3K10

Class: DEG_SCF_FBW7_1

Location: 781:788

E3 ligase: FBXW7

DEGRON score: 0.9658

ASA_SCORE: 98.7125

COIL: 0.9756

CONS_SCORE: 0.2733

DSS_SCORE: 0.8425

HELIX: 0.0103

FCONS_SCORE: 1.0318

RIG_SCORE: 0.4411

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P781L	TCGA-DA-A3F8	SKCM	TCGA	PAPTPTPS	DEG_SCF_FBW7_1	0.6471
p.P781L	DO37418	SKCM	ICGC	PAPTPTPS	DEG_SCF_FBW7_1	0.6471
p.A772T	DO23122	LINC	ICGC	PAPTPTPS	DEG_SCF_FBW7_1	0.0833
p.A772T	ACH-001982	Metastasis	CCLE	PAPTPTPS	DEG_SCF_FBW7_1	0.0833
p.T786M	DO23448	LINC	ICGC	PAPTPTPS	DEG_SCF_FBW7_1	0.6312
p.S779P	DO229208	THCA	ICGC	PAPTPTPS	DEG_SCF_FBW7_1	0.2778
p.S779P	DO229218	THCA	ICGC	PAPTPTPS	DEG_SCF_FBW7_1	0.2778
p.S779P	DO229211	THCA	ICGC	PAPTPTPS	DEG_SCF_FBW7_1	0.2778
p.S779P	DO229229	THCA	ICGC	PAPTPTPS	DEG_SCF_FBW7_1	0.2778
p.S779P	DO229245	THCA	ICGC	PAPTPTPS	DEG_SCF_FBW7_1	0.2778
p.T784K	DO229208	THCA	ICGC	PAPTPTPS	DEG_SCF_FBW7_1	0.7306
p.P780L	DO229542	UTCA	ICGC	PAPTPTPS	DEG_SCF_FBW7_1	0.3056
p.S779F	SIDM01175	Other Sarcomas	GDSC	PAPTPTPS	DEG_SCF_FBW7_1	0.2778
p.S779F	SIDM00333	Endometrial Carcinoma	GDSC	PAPTPTPS	DEG_SCF_FBW7_1	0.2778
p.S779F	ACH-000988	Endometrial/Uterine Cancer	CCLE	PAPTPTPS	DEG_SCF_FBW7_1	0.2778
p.A772G	SIDM00552	Rhabdomyosarcoma	GDSC	PAPTPTPS	DEG_SCF_FBW7_1	0.0833
p.A772G	SIDM01685	B-Lymphoblastic Leukemia	GDSC	PAPTPTPS	DEG_SCF_FBW7_1	0.0833
p.A772G	SIDM01619	Endometrial Carcinoma	GDSC	PAPTPTPS	DEG_SCF_FBW7_1	0.0833
p.A772G	KYM-1	soft_tissue	COSMIC	PAPTPTPS	DEG_SCF_FBW7_1	0.0833
p.P783L	ACH-000947	Ovarian Cancer	CCLE	PAPTPTPS	DEG_SCF_FBW7_1	0.6471
p.A782T	ACH-000954	Endometrial/Uterine Cancer	CCLE	PAPTPTPS	DEG_SCF_FBW7_1	0.6028
p.T786A	ACH-001719	Ovarian Cancer	CCLE	PAPTPTPS	DEG_SCF_FBW7_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02779	Mitogen-activated protein kinase kinase kinase 10	DEG_SCF_FBW7_1	781:788	PAPTPTPS	FBXW7	0.9658	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons