DegronMD - Q02962(PAX2)

GO - Biological processes (BP): aging [GO:0007568]; anatomical structure development [GO:0048856]; axonogenesis [GO:0007409]; brain morphogenesis [GO:0048854]; branching involved in ureteric bud morphogenesis [GO:0001658]; camera-type eye development [GO:0043010]; cell fate determination [GO:0001709]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to glucose stimulus [GO:0071333]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to retinoic acid [GO:0071300]; cochlea development [GO:0090102]; cochlea morphogenesis [GO:0090103]; glial cell differentiation [GO:0010001]; inner ear morphogenesis [GO:0042472]; mesenchymal to epithelial transition [GO:0060231]; mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337]; mesodermal cell fate specification [GO:0007501]; mesonephros development [GO:0001823]; metanephric collecting duct development [GO:0072205]; metanephric distal convoluted tubule development [GO:0072221]; metanephric epithelium development [GO:0072207]; metanephric mesenchymal cell differentiation [GO:0072162]; metanephric mesenchyme development [GO:0072075]; metanephric nephron tubule formation [GO:0072289]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic process involved in metanephric collecting duct development [GO:1900215]; negative regulation of apoptotic process involved in metanephric nephron tubule development [GO:1900218]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis [GO:0072305]; negative regulation of mesenchymal cell apoptotic process involved in metanephros development [GO:1900212]; negative regulation of programmed cell death [GO:0043069]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of transcription, DNA-templated [GO:0045892]; nephric duct formation [GO:0072179]; neural tube closure [GO:0001843]; optic chiasma development [GO:0061360]; optic cup morphogenesis involved in camera-type eye development [GO:0002072]; optic nerve development [GO:0021554]; optic nerve morphogenesis [GO:0021631]; optic nerve structural organization [GO:0021633]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0072108]; positive regulation of metanephric DCT cell differentiation [GO:2000594]; positive regulation of metanephric glomerulus development [GO:0072300]; positive regulation of optic nerve formation [GO:2000597]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; pronephric field specification [GO:0039003]; pronephros development [GO:0048793]; protein kinase B signaling [GO:0043491]; reactive oxygen species metabolic process [GO:0072593]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; regulation of metanephros size [GO:0035566]; regulation of transcription by RNA polymerase II [GO:0006357]; response to nutrient levels [GO:0031667]; retinal pigment epithelium development [GO:0003406]; stem cell differentiation [GO:0048863]; ureter development [GO:0072189]; ureter maturation [GO:0035799]; urogenital system development [GO:0001655]; vestibulocochlear nerve formation [GO:0021650]; visual perception [GO:0007601] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L221F	TCGA-78-7154	LUAD	TCGA	VEVYTD	LIG_APCC_ABBA_1	206:211	Mutation rewiring degron network	0.0556
p.L221F	DO24070	LUAD	ICGC	VEVYTD	LIG_APCC_ABBA_1	206:211	Mutation rewiring degron network	0.0556
p.G217E	TCGA-D3-A51R	SKCM	TCGA	VEVYTD	LIG_APCC_ABBA_1	206:211	Mutation rewiring degron network	0.1667
p.G217E	DO47480	SKCM	ICGC	VEVYTD	LIG_APCC_ABBA_1	206:211	Mutation rewiring degron network	0.1667
p.G220C	TCGA-EY-A1GU	UCEC	TCGA	VEVYTD	LIG_APCC_ABBA_1	206:211	Mutation rewiring degron network	0.0833
p.G220C	DO41518	UCEC	ICGC	VEVYTD	LIG_APCC_ABBA_1	206:211	Mutation rewiring degron network	0.0833
p.K202E	TCGA-HT-A61B	LGG	TCGA	VEVYTD	LIG_APCC_ABBA_1	206:211	Mutation substituting flanking lysine	0.3333
p.K202E	DO219812	LGG	ICGC	VEVYTD	LIG_APCC_ABBA_1	206:211	Mutation substituting flanking lysine	0.3333
p.E207K	TCGA-WE-A8K1	SKCM	TCGA	VEVYTD	LIG_APCC_ABBA_1	206:211	Mutation altering degron motif	0.591
p.E207K	DO51280	SKCM	ICGC	VEVYTD	LIG_APCC_ABBA_1	206:211	Mutation altering degron motif	0.591
p.E207D	DO228985	LICA	ICGC	VEVYTD	LIG_APCC_ABBA_1	206:211	Mutation altering degron motif	0.5647
p.E207D	DO229037	LICA	ICGC	VEVYTD	LIG_APCC_ABBA_1	206:211	Mutation altering degron motif	0.5647
p.P212S	DO220896	MELA	ICGC	VEVYTD	LIG_APCC_ABBA_1	206:211	Mutation rewiring degron network	0.3056
p.P213R	SIDM01700	Hodgkin's Lymphoma	GDSC	VEVYTD	LIG_APCC_ABBA_1	206:211	Mutation rewiring degron network	0.2778
p.P213R	ACH-000165	Non-Cancerous	CCLE	VEVYTD	LIG_APCC_ABBA_1	206:211	Mutation rewiring degron network	0.2778
p.S219N	SIDM01451	Pancreatic Carcinoma	GDSC	VEVYTD	LIG_APCC_ABBA_1	206:211	Mutation rewiring degron network	0.1111
p.S219N	ACH-000933	Pancreatic Cancer	CCLE	VEVYTD	LIG_APCC_ABBA_1	206:211	Mutation rewiring degron network	0.1111
p.N214S	ACH-000829	Myeloma	CCLE	VEVYTD	LIG_APCC_ABBA_1	206:211	Mutation rewiring degron network	0.25
p.T210A	ACH-001641	Head and Neck Cancer	CCLE	VEVYTD	LIG_APCC_ABBA_1	206:211	Mutation altering degron motif	0.6028
p.T210A	SAT	upper aerodigestive tract	COSMIC	VEVYTD	LIG_APCC_ABBA_1	206:211	Mutation altering degron motif	0.6028

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PAX2

UniProt ID: Q02962

Entrez ID: 5076

Protein name: Paired box protein Pax-2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PAX2 in