DegronMD

Uniprot ID: Q02962

Source protein: Paired box protein Pax-2

Source gene: PAX2

Class: LIG_APCC_ABBA_1

Location: 206:211

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7247

ASA_SCORE: 71.6

COIL: 0.6413

CONS_SCORE: 0.3421

DSS_SCORE: 0.4937

HELIX: 0.102

FCONS_SCORE: 0.882

RIG_SCORE: 0.8206

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L221F	TCGA-78-7154	LUAD	TCGA	VEVYTD	LIG_APCC_ABBA_1	0.0556
p.L221F	DO24070	LUAD	ICGC	VEVYTD	LIG_APCC_ABBA_1	0.0556
p.G217E	TCGA-D3-A51R	SKCM	TCGA	VEVYTD	LIG_APCC_ABBA_1	0.1667
p.G217E	DO47480	SKCM	ICGC	VEVYTD	LIG_APCC_ABBA_1	0.1667
p.G220C	TCGA-EY-A1GU	UCEC	TCGA	VEVYTD	LIG_APCC_ABBA_1	0.0833
p.G220C	DO41518	UCEC	ICGC	VEVYTD	LIG_APCC_ABBA_1	0.0833
p.K202E	TCGA-HT-A61B	LGG	TCGA	VEVYTD	LIG_APCC_ABBA_1	0.3333
p.K202E	DO219812	LGG	ICGC	VEVYTD	LIG_APCC_ABBA_1	0.3333
p.E207K	TCGA-WE-A8K1	SKCM	TCGA	VEVYTD	LIG_APCC_ABBA_1	0.591
p.E207K	DO51280	SKCM	ICGC	VEVYTD	LIG_APCC_ABBA_1	0.591
p.E207D	DO228985	LICA	ICGC	VEVYTD	LIG_APCC_ABBA_1	0.5647
p.E207D	DO229037	LICA	ICGC	VEVYTD	LIG_APCC_ABBA_1	0.5647
p.P212S	DO220896	MELA	ICGC	VEVYTD	LIG_APCC_ABBA_1	0.3056
p.P213R	SIDM01700	Hodgkin's Lymphoma	GDSC	VEVYTD	LIG_APCC_ABBA_1	0.2778
p.P213R	ACH-000165	Non-Cancerous	CCLE	VEVYTD	LIG_APCC_ABBA_1	0.2778
p.S219N	SIDM01451	Pancreatic Carcinoma	GDSC	VEVYTD	LIG_APCC_ABBA_1	0.1111
p.S219N	ACH-000933	Pancreatic Cancer	CCLE	VEVYTD	LIG_APCC_ABBA_1	0.1111
p.N214S	ACH-000829	Myeloma	CCLE	VEVYTD	LIG_APCC_ABBA_1	0.25
p.T210A	ACH-001641	Head and Neck Cancer	CCLE	VEVYTD	LIG_APCC_ABBA_1	0.6028
p.T210A	SAT	upper_aerodigestive_tract	COSMIC	VEVYTD	LIG_APCC_ABBA_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02962	Paired box protein Pax-2	LIG_APCC_ABBA_1	206:211	VEVYTD	APC,CDC20,FZR1	0.7247	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons