DegronMD - Q03519(TAP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q450E	TCGA-19-1788	GBM	TCGA	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation rewiring degron network	0.0833
p.Q450E	DO12712	GBM	ICGC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation rewiring degron network	0.0833
p.R480S	TCGA-D3-A2JL	SKCM	TCGA	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation rewiring degron network	0.0556
p.R480S	DO47278	SKCM	ICGC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation rewiring degron network	0.0556
p.R449Q	TCGA-EE-A2MI	SKCM	TCGA	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation rewiring degron network	0.0556
p.R449Q	DO37531	SKCM	ICGC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation rewiring degron network	0.0556
p.R480H	TCGA-EI-6881	READ	TCGA	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation rewiring degron network	0.0556
p.R480H	DO37098	READ	ICGC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation rewiring degron network	0.0556
p.P461S	TCGA-FW-A3R5	SKCM	TCGA	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation altering degron motif	0.6752
p.P461S	DO37406	SKCM	ICGC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation altering degron motif	0.6752
p.P461S	ACH-001461	Colon/Colorectal Cancer	CCLE	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation altering degron motif	0.6752
p.L464V	DO230961	LUSC	ICGC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation altering degron motif	0.5654
p.L464V	DO224594	LUSC	ICGC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation altering degron motif	0.5654
p.R480C	DO222494	MELA	ICGC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation rewiring degron network	0.0556
p.V468A	DO47240	RECA	ICGC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation altering degron motif	0.6936
p.V468A	SIDM01587	Bladder Carcinoma	GDSC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation altering degron motif	0.6936
p.V468A	ACH-000753	Bladder Cancer	CCLE	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation altering degron motif	0.6936
p.V473I	DO234133	THCA	ICGC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation rewiring degron network	0.25
p.V467I	SIDM00330	Neuroblastoma	GDSC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation altering degron motif	0.5965
p.V467I	SIDM01129	Small Cell Lung Carcinoma	GDSC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation altering degron motif	0.5965
p.V467I	SIDM01133	Other Solid Cancers	GDSC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation altering degron motif	0.5965
p.V467I	SIDM00724	Non-Small Cell Lung Carcinoma	GDSC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation altering degron motif	0.5965
p.V467I	SIDM00785	Acute Myeloid Leukemia	GDSC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation altering degron motif	0.5965
p.G457D	SIDM00516	Melanoma	GDSC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation rewiring degron network	0.2778
p.G457D	ACH-002166	Skin Cancer	CCLE	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation rewiring degron network	0.2778
p.G457D	MZ7-mel	skin	COSMIC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	459:470	Mutation rewiring degron network	0.2778

Kaplan plot for TAP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TAP2

UniProt ID: Q03519

Entrez ID: 6891

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TAP2 in