DegronMD

Uniprot ID: Q03519

Source protein: Antigen peptide transporter 2

Source gene: TAP2

Class: DEG_ODPH_VHL_1

Location: 459:470

E3 ligase: VHL

DEGRON score: 0.699

ASA_SCORE: 57.9167

COIL: 0.503

CONS_SCORE: 0.4416

DSS_SCORE: 0.3335

HELIX: 0.0208

FCONS_SCORE: 0.9399

RIG_SCORE: 0.7765

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q450E	TCGA-19-1788	GBM	TCGA	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.0833
p.Q450E	DO12712	GBM	ICGC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.0833
p.R480S	TCGA-D3-A2JL	SKCM	TCGA	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.0556
p.R480S	DO47278	SKCM	ICGC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.0556
p.R449Q	TCGA-EE-A2MI	SKCM	TCGA	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.0556
p.R449Q	DO37531	SKCM	ICGC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.0556
p.R480H	TCGA-EI-6881	READ	TCGA	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.0556
p.R480H	DO37098	READ	ICGC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.0556
p.P461S	TCGA-FW-A3R5	SKCM	TCGA	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.6752
p.P461S	DO37406	SKCM	ICGC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.6752
p.P461S	ACH-001461	Colon/Colorectal Cancer	CCLE	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.6752
p.L464V	DO230961	LUSC	ICGC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.5654
p.L464V	DO224594	LUSC	ICGC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.5654
p.R480C	DO222494	MELA	ICGC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.0556
p.V468A	DO47240	RECA	ICGC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.6936
p.V468A	SIDM01587	Bladder Carcinoma	GDSC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.6936
p.V468A	ACH-000753	Bladder Cancer	CCLE	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.6936
p.V473I	DO234133	THCA	ICGC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.25
p.V467I	SIDM00330	Neuroblastoma	GDSC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.5965
p.V467I	SIDM01129	Small Cell Lung Carcinoma	GDSC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.5965
p.V467I	SIDM01133	Other Solid Cancers	GDSC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.5965
p.V467I	SIDM00724	Non-Small Cell Lung Carcinoma	GDSC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.5965
p.V467I	SIDM00785	Acute Myeloid Leukemia	GDSC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.5965
p.G457D	SIDM00516	Melanoma	GDSC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.2778
p.G457D	ACH-002166	Skin Cancer	CCLE	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.2778
p.G457D	MZ7-mel	skin	COSMIC	LAPTTLQGVVKF	DEG_ODPH_VHL_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPTTLQGVVKF

Degron related mutations and impact score

Drug responses associated with TAP2 mutations

All proteins holding degron of LAPTTLQGVVKF

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03519	Antigen peptide transporter 2	DEG_ODPH_VHL_1	459:470	LAPTTLQGVVKF	VHL	0.699	More...