DegronMD - Q05516(ZBTB16)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D270E	TCGA-24-1417	OV	TCGA	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.0556
p.D270E	DO32019	OV	ICGC	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.0556
p.S287N	TCGA-29-1768	OV	TCGA	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.3056
p.S287N	DO31694	OV	ICGC	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.3056
p.G281R	TCGA-33-AASD	LUSC	TCGA	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation altering degron motif	0.6457
p.G281R	DO219127	LUSC	ICGC	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation altering degron motif	0.6457
p.S287R	TCGA-61-2094	OV	TCGA	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.3056
p.S287R	DO29468	OV	ICGC	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.3056
p.P283Q	TCGA-BF-A1Q0	SKCM	TCGA	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation altering degron motif	0.7035
p.P283Q	DO47374	SKCM	ICGC	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation altering degron motif	0.7035
p.V288I	TCGA-BR-4370	STAD	TCGA	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.2778
p.V288I	DO38499	STAD	ICGC	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.2778
p.L295Q	TCGA-CV-A45W	HNSC	TCGA	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.0833
p.L295Q	DO52060	HNSC	ICGC	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.0833
p.S287I	TCGA-DF-A2KU	UCEC	TCGA	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.3056
p.S287I	DO223286	UCEC	ICGC	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.3056
p.D270N	TCGA-EB-A6R0	SKCM	TCGA	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.0556
p.D270N	DO48646	SKCM	ICGC	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.0556
p.T290I	TCGA-EE-A29D	SKCM	TCGA	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.2222
p.T290I	DO38123	SKCM	ICGC	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.2222
p.E273K	TCGA-EK-A2RB	CESC	TCGA	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.1389
p.E273K	DO48989	CESC	ICGC	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.1389
p.V288A	TCGA-FI-A2D5	UCEC	TCGA	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.2778
p.V288A	DO41331	UCEC	ICGC	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.2778
p.E274K	TCGA-FW-A3R5	SKCM	TCGA	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.1667
p.E274K	DO37406	SKCM	ICGC	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.1667
p.E278Q	TCGA-G2-A2EO	BLCA	TCGA	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.2778
p.E278Q	DO456	BLCA	ICGC	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.2778
p.P283L	DO234319	ESAD	ICGC	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation altering degron motif	0.7582
p.R293S	DO230535	LUSC	ICGC	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.1389
p.R285Q	DO222843	MELA	ICGC	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation altering degron motif	0.6218
p.R293M	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.1389
p.R293M	ACH-002222	Leukemia	CCLE	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.1389
p.R293M	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.1389
p.L295I	ACH-000238	Head and Neck Cancer	CCLE	PGTPTRS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.0833

Kaplan plot for ZBTB16 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZBTB16

UniProt ID: Q05516

Entrez ID: 7704

Protein name: Zinc finger and BTB domain-containing protein 16 (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145) (Zinc finger protein PLZF)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZBTB16 in