DegronMD

Uniprot ID: Q05516

Source protein: Zinc finger and BTB domain-containing protein 16

Source gene: ZBTB16

Class: DEG_SCF_FBW7_1

Location: 280:286

E3 ligase: FBXW7

DEGRON score: 0.9929

ASA_SCORE: 73.8571

COIL: 0.8273

CONS_SCORE: 0.8853

DSS_SCORE: 0.7384

HELIX: 0.0589

FCONS_SCORE: 1.164

RIG_SCORE: 0.5864

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D270E	TCGA-24-1417	OV	TCGA	PGTPTRS	DEG_SCF_FBW7_1	0.0556
p.D270E	DO32019	OV	ICGC	PGTPTRS	DEG_SCF_FBW7_1	0.0556
p.S287N	TCGA-29-1768	OV	TCGA	PGTPTRS	DEG_SCF_FBW7_1	0.3056
p.S287N	DO31694	OV	ICGC	PGTPTRS	DEG_SCF_FBW7_1	0.3056
p.G281R	TCGA-33-AASD	LUSC	TCGA	PGTPTRS	DEG_SCF_FBW7_1	0.6457
p.G281R	DO219127	LUSC	ICGC	PGTPTRS	DEG_SCF_FBW7_1	0.6457
p.S287R	TCGA-61-2094	OV	TCGA	PGTPTRS	DEG_SCF_FBW7_1	0.3056
p.S287R	DO29468	OV	ICGC	PGTPTRS	DEG_SCF_FBW7_1	0.3056
p.P283Q	TCGA-BF-A1Q0	SKCM	TCGA	PGTPTRS	DEG_SCF_FBW7_1	0.7035
p.P283Q	DO47374	SKCM	ICGC	PGTPTRS	DEG_SCF_FBW7_1	0.7035
p.V288I	TCGA-BR-4370	STAD	TCGA	PGTPTRS	DEG_SCF_FBW7_1	0.2778
p.V288I	DO38499	STAD	ICGC	PGTPTRS	DEG_SCF_FBW7_1	0.2778
p.L295Q	TCGA-CV-A45W	HNSC	TCGA	PGTPTRS	DEG_SCF_FBW7_1	0.0833
p.L295Q	DO52060	HNSC	ICGC	PGTPTRS	DEG_SCF_FBW7_1	0.0833
p.S287I	TCGA-DF-A2KU	UCEC	TCGA	PGTPTRS	DEG_SCF_FBW7_1	0.3056
p.S287I	DO223286	UCEC	ICGC	PGTPTRS	DEG_SCF_FBW7_1	0.3056
p.D270N	TCGA-EB-A6R0	SKCM	TCGA	PGTPTRS	DEG_SCF_FBW7_1	0.0556
p.D270N	DO48646	SKCM	ICGC	PGTPTRS	DEG_SCF_FBW7_1	0.0556
p.T290I	TCGA-EE-A29D	SKCM	TCGA	PGTPTRS	DEG_SCF_FBW7_1	0.2222
p.T290I	DO38123	SKCM	ICGC	PGTPTRS	DEG_SCF_FBW7_1	0.2222
p.E273K	TCGA-EK-A2RB	CESC	TCGA	PGTPTRS	DEG_SCF_FBW7_1	0.1389
p.E273K	DO48989	CESC	ICGC	PGTPTRS	DEG_SCF_FBW7_1	0.1389
p.V288A	TCGA-FI-A2D5	UCEC	TCGA	PGTPTRS	DEG_SCF_FBW7_1	0.2778
p.V288A	DO41331	UCEC	ICGC	PGTPTRS	DEG_SCF_FBW7_1	0.2778
p.E274K	TCGA-FW-A3R5	SKCM	TCGA	PGTPTRS	DEG_SCF_FBW7_1	0.1667
p.E274K	DO37406	SKCM	ICGC	PGTPTRS	DEG_SCF_FBW7_1	0.1667
p.E278Q	TCGA-G2-A2EO	BLCA	TCGA	PGTPTRS	DEG_SCF_FBW7_1	0.2778
p.E278Q	DO456	BLCA	ICGC	PGTPTRS	DEG_SCF_FBW7_1	0.2778
p.P283L	DO234319	ESAD	ICGC	PGTPTRS	DEG_SCF_FBW7_1	0.7582
p.R293S	DO230535	LUSC	ICGC	PGTPTRS	DEG_SCF_FBW7_1	0.1389
p.R285Q	DO222843	MELA	ICGC	PGTPTRS	DEG_SCF_FBW7_1	0.6218
p.R293M	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PGTPTRS	DEG_SCF_FBW7_1	0.1389
p.R293M	ACH-002222	Leukemia	CCLE	PGTPTRS	DEG_SCF_FBW7_1	0.1389
p.R293M	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PGTPTRS	DEG_SCF_FBW7_1	0.1389
p.L295I	ACH-000238	Head and Neck Cancer	CCLE	PGTPTRS	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTPTRS

Degron related mutations and impact score

Drug responses associated with ZBTB16 mutations

All proteins holding degron of PGTPTRS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q05516	Zinc finger and BTB domain-containing protein 16	DEG_SCF_FBW7_1	280:286	PGTPTRS	FBXW7	0.9929	More...