DegronMD - Q05BV3(EML5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D625N	TCGA-W3-AA1V	SKCM	TCGA	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation altering degron motif	0.5821
p.D625N	DO51276	SKCM	ICGC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation altering degron motif	0.5821
p.D625V	DO222637	BTCA	ICGC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation altering degron motif	0.6674
p.E628Q	DO48246	ESCA	ICGC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation altering degron motif	0.6744
p.S616N	DO229177	LMS	ICGC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.3056
p.I633V	SIDM00961	Ewing's Sarcoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2222
p.I633V	SIDM00352	Ovarian Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2222
p.I633V	SIDM01242	Melanoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2222
p.I633V	SIDM00358	Gastric Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2222
p.I633V	SIDM00585	Hepatocellular Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2222
p.I633V	SIDM00251	Gastric Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2222
p.I633V	SIDM00242	Osteosarcoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2222
p.I633V	SIDM00271	Gastric Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2222
p.I633V	SIDM00363	Acute Myeloid Leukemia	GDSC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2222
p.I633V	SIDM00531	Pancreatic Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2222
p.I633V	SIDM01439	Hepatocellular Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2222
p.I633V	SIDM01659	Kidney Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2222
p.I633V	SIDM01377	Ovarian Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2222
p.I633V	SIDM01776	Plasma Cell Myeloma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2222
p.I633V	SIDM01454	Kidney Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2222
p.I633V	SIDM01782	Oral Cavity Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2222
p.I633V	SIDM01574	Plasma Cell Myeloma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2222
p.I633V	CADO-ES1	bone	COSMIC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2222
p.Q638H	SIDM00111	Glioma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.0833
p.Q638H	ACH-000232	Brain Cancer	CCLE	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.0833
p.Q638H	ACH-001172	Brain Cancer	CCLE	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.0833
p.Q638H	U251	central nervous system	COSMIC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.0833
p.E634Q	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.1944
p.E634Q	ACH-000892	Lung Cancer	CCLE	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.1944
p.E634Q	NCI-H1563	lung	COSMIC	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.1944
p.D617Y	ACH-001853	Bile Duct Cancer	CCLE	DESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation altering degron motif	0.7325

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EML5

UniProt ID: Q05BV3

Entrez ID: 161436

Protein name: Echinoderm microtubule-associated protein-like 5 (EMAP-5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EML5 in