DegronMD

Uniprot ID: Q05BV3

Source protein: Echinoderm microtubule-associated protein-like 5

Source gene: EML5

Class: DEG_COP1_1

Location: 617:629

E3 ligase: COP1

DEGRON score: 0.9196

ASA_SCORE: 72.4615

COIL: 0.7915

CONS_SCORE: 0.5902

DSS_SCORE: 0.702

HELIX: 0.1481

FCONS_SCORE: 1.0892

RIG_SCORE: 0.6279

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D625N	TCGA-W3-AA1V	SKCM	TCGA	DESDSDLSDVPEL	DEG_COP1_1	0.5821
p.D625N	DO51276	SKCM	ICGC	DESDSDLSDVPEL	DEG_COP1_1	0.5821
p.D625V	DO222637	BTCA	ICGC	DESDSDLSDVPEL	DEG_COP1_1	0.6674
p.E628Q	DO48246	ESCA	ICGC	DESDSDLSDVPEL	DEG_COP1_1	0.6744
p.S616N	DO229177	LMS	ICGC	DESDSDLSDVPEL	DEG_COP1_1	0.3056
p.I633V	SIDM00961	Ewing's Sarcoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM00352	Ovarian Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM01242	Melanoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM00358	Gastric Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM00585	Hepatocellular Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM00251	Gastric Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM00242	Osteosarcoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM00271	Gastric Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM00363	Acute Myeloid Leukemia	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM00531	Pancreatic Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM01439	Hepatocellular Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM01659	Kidney Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM01377	Ovarian Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM01776	Plasma Cell Myeloma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM01454	Kidney Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM01782	Oral Cavity Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM01574	Plasma Cell Myeloma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	CADO-ES1	bone	COSMIC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.Q638H	SIDM00111	Glioma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.0833
p.Q638H	ACH-000232	Brain Cancer	CCLE	DESDSDLSDVPEL	DEG_COP1_1	0.0833
p.Q638H	ACH-001172	Brain Cancer	CCLE	DESDSDLSDVPEL	DEG_COP1_1	0.0833
p.Q638H	U251	central_nervous_system	COSMIC	DESDSDLSDVPEL	DEG_COP1_1	0.0833
p.E634Q	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.1944
p.E634Q	ACH-000892	Lung Cancer	CCLE	DESDSDLSDVPEL	DEG_COP1_1	0.1944
p.E634Q	NCI-H1563	lung	COSMIC	DESDSDLSDVPEL	DEG_COP1_1	0.1944
p.D617Y	ACH-001853	Bile Duct Cancer	CCLE	DESDSDLSDVPEL	DEG_COP1_1	0.7325

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DESDSDLSDVPEL

Degron related mutations and impact score

Drug responses associated with EML5 mutations

All proteins holding degron of DESDSDLSDVPEL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q05BV3	Echinoderm microtubule-associated protein-like 5	DEG_COP1_1	617:629	DESDSDLSDVPEL	COP1	0.9196	More...