DegronMD

Uniprot ID: Q05BV3

Source protein: Echinoderm microtubule-associated protein-like 5

Source gene: EML5

Class: DEG_COP1_1

Location: 617:629

E3 ligase: COP1

DEGRON score: 0.9196

ASA_SCORE: 72.4615

COIL: 0.7915

CONS_SCORE: 0.5902

DSS_SCORE: 0.702

HELIX: 0.1481

FCONS_SCORE: 1.0892

RIG_SCORE: 0.6279

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D617Y	ACH-001853	Bile Duct Cancer	CCLE	DESDSDLSDVPEL	DEG_COP1_1	0.7325
p.E628Q	DO48246	ESCA	ICGC	DESDSDLSDVPEL	DEG_COP1_1	0.6744
p.D625V	DO222637	BTCA	ICGC	DESDSDLSDVPEL	DEG_COP1_1	0.6674
p.D625N	TCGA-W3-AA1V	SKCM	TCGA	DESDSDLSDVPEL	DEG_COP1_1	0.5821
p.D625N	DO51276	SKCM	ICGC	DESDSDLSDVPEL	DEG_COP1_1	0.5821
p.S616N	DO229177	LMS	ICGC	DESDSDLSDVPEL	DEG_COP1_1	0.3056
p.I633V	SIDM00961	Ewing's Sarcoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM00352	Ovarian Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM01242	Melanoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM00358	Gastric Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM00585	Hepatocellular Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM00251	Gastric Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM00242	Osteosarcoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM00271	Gastric Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM00363	Acute Myeloid Leukemia	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM00531	Pancreatic Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM01439	Hepatocellular Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM01659	Kidney Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM01377	Ovarian Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM01776	Plasma Cell Myeloma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM01454	Kidney Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM01782	Oral Cavity Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	SIDM01574	Plasma Cell Myeloma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.I633V	CADO-ES1	bone	COSMIC	DESDSDLSDVPEL	DEG_COP1_1	0.2222
p.E634Q	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	DESDSDLSDVPEL	DEG_COP1_1	0.1944

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Drug responses associated with EML5 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of DESDSDLSDVPEL

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q05BV3	Echinoderm microtubule-associated protein-like 5	DEG_COP1_1	617:629	DESDSDLSDVPEL	COP1	0.9196	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DESDSDLSDVPEL

Degron related mutations and impact score

Drug responses associated with EML5 mutations

All proteins holding degron of DESDSDLSDVPEL