DegronMD - Q05C16(LRRC63)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S197G	TCGA-DF-A2KN	UCEC	TCGA	DLSATVPSP	DEG_COP1_1	195:203	Mutation altering degron motif	0.6993
p.S197G	DO223282	UCEC	ICGC	DLSATVPSP	DEG_COP1_1	195:203	Mutation altering degron motif	0.6993
p.S193L	TCGA-LP-A4AX	CESC	TCGA	DLSATVPSP	DEG_COP1_1	195:203	Mutation rewiring degron network	0.2778
p.S193L	DO44358	CESC	ICGC	DLSATVPSP	DEG_COP1_1	195:203	Mutation rewiring degron network	0.2778
p.S209F	TCGA-W5-AA39	CHOL	TCGA	DLSATVPSP	DEG_COP1_1	195:203	Mutation rewiring degron network	0.1667
p.M206V	DO229013	COCA	ICGC	DLSATVPSP	DEG_COP1_1	195:203	Mutation rewiring degron network	0.25
p.M206V	DO229480	LAML	ICGC	DLSATVPSP	DEG_COP1_1	195:203	Mutation rewiring degron network	0.25
p.M206V	DO230525	LUSC	ICGC	DLSATVPSP	DEG_COP1_1	195:203	Mutation rewiring degron network	0.25
p.S197R	DO234395	ESAD	ICGC	DLSATVPSP	DEG_COP1_1	195:203	Mutation altering degron motif	0.7427
p.S197R	DO227531	PACA	ICGC	DLSATVPSP	DEG_COP1_1	195:203	Mutation altering degron motif	0.7427
p.D195Y	DO232224	PBCA	ICGC	DLSATVPSP	DEG_COP1_1	195:203	Mutation altering degron motif	0.7325
p.T188S	DO232675	PBCA	ICGC	DLSATVPSP	DEG_COP1_1	195:203	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons