DegronMD

Uniprot ID: Q05C16

Source protein: Leucine-rich repeat-containing protein 63

Source gene: LRRC63

Class: DEG_COP1_1

Location: 195:203

E3 ligase: COP1

DEGRON score: 0.9458

ASA_SCORE: 53.1111

COIL: 0.6868

CONS_SCORE: 0.4537

DSS_SCORE: 0.5975

HELIX: 0.0273

FCONS_SCORE: 0.9477

RIG_SCORE: 0.63

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S197G	TCGA-DF-A2KN	UCEC	TCGA	DLSATVPSP	DEG_COP1_1	0.6993
p.S197G	DO223282	UCEC	ICGC	DLSATVPSP	DEG_COP1_1	0.6993
p.S193L	TCGA-LP-A4AX	CESC	TCGA	DLSATVPSP	DEG_COP1_1	0.2778
p.S193L	DO44358	CESC	ICGC	DLSATVPSP	DEG_COP1_1	0.2778
p.S209F	TCGA-W5-AA39	CHOL	TCGA	DLSATVPSP	DEG_COP1_1	0.1667
p.M206V	DO229013	COCA	ICGC	DLSATVPSP	DEG_COP1_1	0.25
p.M206V	DO229480	LAML	ICGC	DLSATVPSP	DEG_COP1_1	0.25
p.M206V	DO230525	LUSC	ICGC	DLSATVPSP	DEG_COP1_1	0.25
p.S197R	DO234395	ESAD	ICGC	DLSATVPSP	DEG_COP1_1	0.7427
p.S197R	DO227531	PACA	ICGC	DLSATVPSP	DEG_COP1_1	0.7427
p.D195Y	DO232224	PBCA	ICGC	DLSATVPSP	DEG_COP1_1	0.7325
p.T188S	DO232675	PBCA	ICGC	DLSATVPSP	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q05C16	Leucine-rich repeat-containing protein 63	DEG_COP1_1	195:203	DLSATVPSP	COP1	0.9458	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons