DegronMD - Q06203(PPAT)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S145C	TCGA-29-1775	OV	TCGA	LAYTPPQE	DEG_SCF_FBW7_2	155:162	Mutation rewiring degron network	0.0556
p.S145C	DO30870	OV	ICGC	LAYTPPQE	DEG_SCF_FBW7_2	155:162	Mutation rewiring degron network	0.0556
p.P167T	TCGA-AA-3877	COAD	TCGA	LAYTPPQE	DEG_SCF_FBW7_2	155:162	Mutation rewiring degron network	0.1944
p.P167T	DO7855	COAD	ICGC	LAYTPPQE	DEG_SCF_FBW7_2	155:162	Mutation rewiring degron network	0.1944
p.P160S	TCGA-CN-5366	HNSC	TCGA	LAYTPPQE	DEG_SCF_FBW7_2	155:162	Mutation altering degron motif	0.5641
p.P160S	DO15182	HNSC	ICGC	LAYTPPQE	DEG_SCF_FBW7_2	155:162	Mutation altering degron motif	0.5641
p.M150I	TCGA-D8-A1JA	BRCA	TCGA	LAYTPPQE	DEG_SCF_FBW7_2	155:162	Mutation rewiring degron network	0.1944
p.M150I	DO2819	BRCA	ICGC	LAYTPPQE	DEG_SCF_FBW7_2	155:162	Mutation rewiring degron network	0.1944
p.A156V	TCGA-FI-A2D5	UCEC	TCGA	LAYTPPQE	DEG_SCF_FBW7_2	155:162	Mutation altering degron motif	0.5825
p.A156V	DO41331	UCEC	ICGC	LAYTPPQE	DEG_SCF_FBW7_2	155:162	Mutation altering degron motif	0.5825
p.D147H	DO48457	BLCA	ICGC	LAYTPPQE	DEG_SCF_FBW7_2	155:162	Mutation rewiring degron network	0.1111
p.D168E	DO229019	LICA	ICGC	LAYTPPQE	DEG_SCF_FBW7_2	155:162	Mutation rewiring degron network	0.1667
p.E149G	DO231824	LINC	ICGC	LAYTPPQE	DEG_SCF_FBW7_2	155:162	Mutation rewiring degron network	0.1667
p.P167L	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	LAYTPPQE	DEG_SCF_FBW7_2	155:162	Mutation rewiring degron network	0.1944
p.P167L	SIDM00789	Colorectal Carcinoma	GDSC	LAYTPPQE	DEG_SCF_FBW7_2	155:162	Mutation rewiring degron network	0.1944
p.P167L	ACH-000587	Lung Cancer	CCLE	LAYTPPQE	DEG_SCF_FBW7_2	155:162	Mutation rewiring degron network	0.1944
p.P167L	ACH-000997	Colon/Colorectal Cancer	CCLE	LAYTPPQE	DEG_SCF_FBW7_2	155:162	Mutation rewiring degron network	0.1944
p.P167L	NCI-H1975	lung	COSMIC	LAYTPPQE	DEG_SCF_FBW7_2	155:162	Mutation rewiring degron network	0.1944
p.P167L	HCT-15	large intestine	COSMIC	LAYTPPQE	DEG_SCF_FBW7_2	155:162	Mutation rewiring degron network	0.1944

Kaplan plot for PPAT in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPAT

UniProt ID: Q06203

Entrez ID: 5471

Protein name: Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPAT)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPAT in