DegronMD

Uniprot ID: Q06203

Source protein: Amidophosphoribosyltransferase

Source gene: PPAT

Class: DEG_SCF_FBW7_2

Location: 155:162

E3 ligase: FBXW7

DEGRON score: 0.6433

ASA_SCORE: 52.5

COIL: 0.6734

CONS_SCORE: 0.325

DSS_SCORE: 0.5139

HELIX: 0.2955

FCONS_SCORE: 0.6675

RIG_SCORE: 0.7314

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S145C	TCGA-29-1775	OV	TCGA	LAYTPPQE	DEG_SCF_FBW7_2	0.0556
p.S145C	DO30870	OV	ICGC	LAYTPPQE	DEG_SCF_FBW7_2	0.0556
p.P167T	TCGA-AA-3877	COAD	TCGA	LAYTPPQE	DEG_SCF_FBW7_2	0.1944
p.P167T	DO7855	COAD	ICGC	LAYTPPQE	DEG_SCF_FBW7_2	0.1944
p.P160S	TCGA-CN-5366	HNSC	TCGA	LAYTPPQE	DEG_SCF_FBW7_2	0.5641
p.P160S	DO15182	HNSC	ICGC	LAYTPPQE	DEG_SCF_FBW7_2	0.5641
p.M150I	TCGA-D8-A1JA	BRCA	TCGA	LAYTPPQE	DEG_SCF_FBW7_2	0.1944
p.M150I	DO2819	BRCA	ICGC	LAYTPPQE	DEG_SCF_FBW7_2	0.1944
p.A156V	TCGA-FI-A2D5	UCEC	TCGA	LAYTPPQE	DEG_SCF_FBW7_2	0.5825
p.A156V	DO41331	UCEC	ICGC	LAYTPPQE	DEG_SCF_FBW7_2	0.5825
p.D147H	DO48457	BLCA	ICGC	LAYTPPQE	DEG_SCF_FBW7_2	0.1111
p.D168E	DO229019	LICA	ICGC	LAYTPPQE	DEG_SCF_FBW7_2	0.1667
p.E149G	DO231824	LINC	ICGC	LAYTPPQE	DEG_SCF_FBW7_2	0.1667
p.P167L	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	LAYTPPQE	DEG_SCF_FBW7_2	0.1944
p.P167L	SIDM00789	Colorectal Carcinoma	GDSC	LAYTPPQE	DEG_SCF_FBW7_2	0.1944
p.P167L	ACH-000587	Lung Cancer	CCLE	LAYTPPQE	DEG_SCF_FBW7_2	0.1944
p.P167L	ACH-000997	Colon/Colorectal Cancer	CCLE	LAYTPPQE	DEG_SCF_FBW7_2	0.1944
p.P167L	NCI-H1975	lung	COSMIC	LAYTPPQE	DEG_SCF_FBW7_2	0.1944
p.P167L	HCT-15	large_intestine	COSMIC	LAYTPPQE	DEG_SCF_FBW7_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q06203	Amidophosphoribosyltransferase	DEG_SCF_FBW7_2	155:162	LAYTPPQE	FBXW7	0.6433	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons