DegronMD - Q06323(PSME1)

PSME1

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D15Y	TCGA-43-3394	LUSC	TCGA	VDVFRE	LIG_APCC_ABBA_1	14:19	Mutation altering degron motif	0.6214
p.D15Y	DO26596	LUSC	ICGC	VDVFRE	LIG_APCC_ABBA_1	14:19	Mutation altering degron motif	0.6214
p.L21F	TCGA-AP-A059	UCEC	TCGA	VDVFRE	LIG_APCC_ABBA_1	14:19	Mutation rewiring degron network	0.2778
p.L21F	DO41361	UCEC	ICGC	VDVFRE	LIG_APCC_ABBA_1	14:19	Mutation rewiring degron network	0.2778
p.K24N	TCGA-EE-A181	SKCM	TCGA	VDVFRE	LIG_APCC_ABBA_1	14:19	Mutation blocking ubiquitination signal	0.6389
p.K24N	DO37444	SKCM	ICGC	VDVFRE	LIG_APCC_ABBA_1	14:19	Mutation blocking ubiquitination signal	0.6389
p.K13N	TCGA-X7-A8M8	THYM	TCGA	VDVFRE	LIG_APCC_ABBA_1	14:19	Mutation blocking ubiquitination signal	0.75
p.A12S	DO232224	PBCA	ICGC	VDVFRE	LIG_APCC_ABBA_1	14:19	Mutation rewiring degron network	0.2778
p.E19K	ACH-000975	Lung Cancer	CCLE	VDVFRE	LIG_APCC_ABBA_1	14:19	Mutation altering degron motif	0.7022
p.G10V	CAL-78	bone	COSMIC	VDVFRE	LIG_APCC_ABBA_1	14:19	Mutation rewiring degron network	0.2222
p.T27N	MKN7	stomach	COSMIC	VDVFRE	LIG_APCC_ABBA_1	14:19	Mutation rewiring degron network	0.1111
p.L4I	639-V	urinary tract	COSMIC	VDVFRE	LIG_APCC_ABBA_1	14:19	Mutation blocking ubiquitination signal	0.5

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*NOTE: the Kaplan plots were collected from OncoLnc