DegronMD

Uniprot ID: Q06323

Source protein: Proteasome activator complex subunit 1

Source gene: PSME1

Class: LIG_APCC_ABBA_1

Location: 14:19

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6345

ASA_SCORE: 58.5333

COIL: 0.0038

CONS_SCORE: 0.4586

DSS_SCORE: 0.26

HELIX: 0.996

FCONS_SCORE: 1.2861

RIG_SCORE: 0.8705

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K13N	TCGA-X7-A8M8	THYM	TCGA	VDVFRE	LIG_APCC_ABBA_1	0.75
p.E19K	ACH-000975	Lung Cancer	CCLE	VDVFRE	LIG_APCC_ABBA_1	0.7022
p.K24N	TCGA-EE-A181	SKCM	TCGA	VDVFRE	LIG_APCC_ABBA_1	0.6389
p.K24N	DO37444	SKCM	ICGC	VDVFRE	LIG_APCC_ABBA_1	0.6389
p.D15Y	TCGA-43-3394	LUSC	TCGA	VDVFRE	LIG_APCC_ABBA_1	0.6214
p.D15Y	DO26596	LUSC	ICGC	VDVFRE	LIG_APCC_ABBA_1	0.6214
p.L4I	639-V	urinary_tract	COSMIC	VDVFRE	LIG_APCC_ABBA_1	0.5
p.L21F	TCGA-AP-A059	UCEC	TCGA	VDVFRE	LIG_APCC_ABBA_1	0.2778
p.L21F	DO41361	UCEC	ICGC	VDVFRE	LIG_APCC_ABBA_1	0.2778
p.A12S	DO232224	PBCA	ICGC	VDVFRE	LIG_APCC_ABBA_1	0.2778
p.G10V	CAL-78	bone	COSMIC	VDVFRE	LIG_APCC_ABBA_1	0.2222
p.T27N	MKN7	stomach	COSMIC	VDVFRE	LIG_APCC_ABBA_1	0.1111

Showing 1 to 12 of 12 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q06323	Proteasome activator complex subunit 1	LIG_APCC_ABBA_1	14:19	VDVFRE	APC,CDC20,FZR1	0.6345	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons