DegronMD - Q06481(APLP2)

APLP2

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A358T	TCGA-3A-A9J0	PAAD	TCGA	IPPTPLPT	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.1667
p.C356S	TCGA-55-7994	LUAD	TCGA	IPPTPLPT	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.1111
p.A362V	TCGA-DF-A2KU	UCEC	TCGA	IPPTPLPT	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.2778
p.A362V	SIDM00216	Colorectal Carcinoma	GDSC	IPPTPLPT	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.2778
p.A362V	ACH-000989	Colon/Colorectal Cancer	CCLE	IPPTPLPT	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.2778
p.A362V	ACH-001369	Ovarian Cancer	CCLE	IPPTPLPT	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.2778
p.A362V	SNU-175	large intestine	COSMIC	IPPTPLPT	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.2778
p.P366A	TCGA-VS-A9UH	CESC	TCGA	IPPTPLPT	DEG_SCF_FBW7_1	364:371	Mutation altering degron motif	0.6392
p.V359M	DO10886	GBM	ICGC	IPPTPLPT	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.1944
p.P368L	DO222714	MELA	ICGC	IPPTPLPT	DEG_SCF_FBW7_1	364:371	Mutation altering degron motif	0.7582
p.P369Q	DO37543	SKCM	ICGC	IPPTPLPT	DEG_SCF_FBW7_1	364:371	Mutation altering degron motif	0.7035
p.E363Q	HT-1197	urinary tract	COSMIC	IPPTPLPT	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.3056
p.A372V	SNU-175	large intestine	COSMIC	IPPTPLPT	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc