DegronMD

Uniprot ID: Q06481

Source protein: Amyloid beta precursor like protein 2

Source gene: APLP2

Class: DEG_SCF_FBW7_1

Location: 364:371

E3 ligase: FBXW7

DEGRON score: 0.6282

ASA_SCORE: 68.15

COIL: 0.9138

CONS_SCORE: 0.354

DSS_SCORE: 0.1995

HELIX: 0.0223

FCONS_SCORE: 1.1224

RIG_SCORE: 0.7312

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P368L	DO222714	MELA	ICGC	IPPTPLPT	DEG_SCF_FBW7_1	0.7582
p.P369Q	DO37543	SKCM	ICGC	IPPTPLPT	DEG_SCF_FBW7_1	0.7035
p.P366A	TCGA-VS-A9UH	CESC	TCGA	IPPTPLPT	DEG_SCF_FBW7_1	0.6392
p.E363Q	HT-1197	urinary_tract	COSMIC	IPPTPLPT	DEG_SCF_FBW7_1	0.3056
p.A372V	SNU-175	large_intestine	COSMIC	IPPTPLPT	DEG_SCF_FBW7_1	0.3056
p.A362V	TCGA-DF-A2KU	UCEC	TCGA	IPPTPLPT	DEG_SCF_FBW7_1	0.2778
p.A362V	SIDM00216	Colorectal Carcinoma	GDSC	IPPTPLPT	DEG_SCF_FBW7_1	0.2778
p.A362V	ACH-000989	Colon/Colorectal Cancer	CCLE	IPPTPLPT	DEG_SCF_FBW7_1	0.2778
p.A362V	ACH-001369	Ovarian Cancer	CCLE	IPPTPLPT	DEG_SCF_FBW7_1	0.2778
p.A362V	SNU-175	large_intestine	COSMIC	IPPTPLPT	DEG_SCF_FBW7_1	0.2778
p.V359M	DO10886	GBM	ICGC	IPPTPLPT	DEG_SCF_FBW7_1	0.1944
p.A358T	TCGA-3A-A9J0	PAAD	TCGA	IPPTPLPT	DEG_SCF_FBW7_1	0.1667
p.C356S	TCGA-55-7994	LUAD	TCGA	IPPTPLPT	DEG_SCF_FBW7_1	0.1111

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q06481	Amyloid beta precursor like protein 2	DEG_SCF_FBW7_1	364:371	IPPTPLPT	FBXW7	0.6282	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons