DegronMD - Q06547(GABPB1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R387H	TCGA-63-A5MW	LUSC	TCGA	YRQKLEAMT	DEG_APCC_DBOX_1	378:386	Mutation rewiring degron network	0.3056
p.R387H	TCGA-B5-A1MR	UCEC	TCGA	YRQKLEAMT	DEG_APCC_DBOX_1	378:386	Mutation rewiring degron network	0.3056
p.R387H	TCGA-CG-4306	STAD	TCGA	YRQKLEAMT	DEG_APCC_DBOX_1	378:386	Mutation rewiring degron network	0.3056
p.Q373K	TCGA-73-A9RS	LUAD	TCGA	YRQKLEAMT	DEG_APCC_DBOX_1	378:386	Mutation rewiring degron network	0.1944
p.R387C	TCGA-B5-A11E	UCEC	TCGA	YRQKLEAMT	DEG_APCC_DBOX_1	378:386	Mutation rewiring degron network	0.3056
p.A384V	TCGA-DU-6392	LGG	TCGA	YRQKLEAMT	DEG_APCC_DBOX_1	378:386	Mutation altering degron motif	0.5825
p.E376D	TCGA-EO-A22U	UCEC	TCGA	YRQKLEAMT	DEG_APCC_DBOX_1	378:386	Mutation rewiring degron network	0.2778
p.A372V	DO22237	LGG	ICGC	YRQKLEAMT	DEG_APCC_DBOX_1	378:386	Mutation rewiring degron network	0.1667
p.R375H	DO219169	LUSC	ICGC	YRQKLEAMT	DEG_APCC_DBOX_1	378:386	Mutation rewiring degron network	0.25
p.R375H	DO38567	STAD	ICGC	YRQKLEAMT	DEG_APCC_DBOX_1	378:386	Mutation rewiring degron network	0.25
p.R375H	DO41758	UCEC	ICGC	YRQKLEAMT	DEG_APCC_DBOX_1	378:386	Mutation rewiring degron network	0.25
p.R375C	DO41644	UCEC	ICGC	YRQKLEAMT	DEG_APCC_DBOX_1	378:386	Mutation rewiring degron network	0.25
p.K370N	SIDM00588	Oral Cavity Carcinoma	GDSC	YRQKLEAMT	DEG_APCC_DBOX_1	378:386	Mutation substituting flanking lysine	0.2222
p.K370N	HSC-4	upper aerodigestive tract	COSMIC	YRQKLEAMT	DEG_APCC_DBOX_1	378:386	Mutation substituting flanking lysine	0.2222
p.A377D	SIDM01007	T-Lymphoblastic Leukemia	GDSC	YRQKLEAMT	DEG_APCC_DBOX_1	378:386	Mutation rewiring degron network	0.3056
p.A377D	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	YRQKLEAMT	DEG_APCC_DBOX_1	378:386	Mutation rewiring degron network	0.3056
p.R387L	ACH-000976	Bile Duct Cancer	CCLE	YRQKLEAMT	DEG_APCC_DBOX_1	378:386	Mutation rewiring degron network	0.3056

Kaplan plot for GABPB1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GABPB1

UniProt ID: Q06547

Entrez ID: 2553

Protein name: GA-binding protein subunit beta-1 (GABP subunit beta-1) (GABPB-1) (GABP subunit beta-2) (GABPB-2) (Nuclear respiratory factor 2) (Transcription factor E4TF1-47) (Transcription factor E4TF1-53)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GABPB1 in