DegronMD

Uniprot ID: Q06547

Source protein: GA-binding protein subunit beta-1

Source gene: GABPB1

Class: DEG_APCC_DBOX_1

Location: 378:386

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6095

ASA_SCORE: 89.6444

COIL: 0.065

CONS_SCORE: 0.6019

DSS_SCORE: 0.4251

HELIX: 0.9363

FCONS_SCORE: 1.0948

RIG_SCORE: 0.7915

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R387H	TCGA-63-A5MW	LUSC	TCGA	YRQKLEAMT	DEG_APCC_DBOX_1	0.3056
p.R387H	TCGA-B5-A1MR	UCEC	TCGA	YRQKLEAMT	DEG_APCC_DBOX_1	0.3056
p.R387H	TCGA-CG-4306	STAD	TCGA	YRQKLEAMT	DEG_APCC_DBOX_1	0.3056
p.Q373K	TCGA-73-A9RS	LUAD	TCGA	YRQKLEAMT	DEG_APCC_DBOX_1	0.1944
p.R387C	TCGA-B5-A11E	UCEC	TCGA	YRQKLEAMT	DEG_APCC_DBOX_1	0.3056
p.A384V	TCGA-DU-6392	LGG	TCGA	YRQKLEAMT	DEG_APCC_DBOX_1	0.5825
p.E376D	TCGA-EO-A22U	UCEC	TCGA	YRQKLEAMT	DEG_APCC_DBOX_1	0.2778
p.A372V	DO22237	LGG	ICGC	YRQKLEAMT	DEG_APCC_DBOX_1	0.1667
p.R375H	DO219169	LUSC	ICGC	YRQKLEAMT	DEG_APCC_DBOX_1	0.25
p.R375H	DO38567	STAD	ICGC	YRQKLEAMT	DEG_APCC_DBOX_1	0.25
p.R375H	DO41758	UCEC	ICGC	YRQKLEAMT	DEG_APCC_DBOX_1	0.25
p.R375C	DO41644	UCEC	ICGC	YRQKLEAMT	DEG_APCC_DBOX_1	0.25
p.K370N	SIDM00588	Oral Cavity Carcinoma	GDSC	YRQKLEAMT	DEG_APCC_DBOX_1	0.2222
p.K370N	HSC-4	upper_aerodigestive_tract	COSMIC	YRQKLEAMT	DEG_APCC_DBOX_1	0.2222
p.A377D	SIDM01007	T-Lymphoblastic Leukemia	GDSC	YRQKLEAMT	DEG_APCC_DBOX_1	0.3056
p.A377D	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	YRQKLEAMT	DEG_APCC_DBOX_1	0.3056
p.R387L	ACH-000976	Bile Duct Cancer	CCLE	YRQKLEAMT	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q06547	GA-binding protein subunit beta-1	DEG_APCC_DBOX_1	378:386	YRQKLEAMT	APC,CDC20,FZR1	0.6095	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons