DegronMD - Q07002(CDK18)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D132N	TCGA-56-A5DS	LUSC	TCGA	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.6932
p.S124G	TCGA-5C-A9VH	LIHC	TCGA	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1944
p.E146D	TCGA-A5-A0G2	UCEC	TCGA	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation blocking ubiquitination signal	0.5278
p.R134H	TCGA-D1-A2G0	UCEC	TCGA	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.8244
p.S147N	TCGA-DA-A1I7	SKCM	TCGA	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.0556
p.R134S	TCGA-DA-A1IB	SKCM	TCGA	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.7427
p.E138D	TCGA-EO-A3B0	UCEC	TCGA	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.3056
p.G139V	DO233906	GACA	ICGC	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.2778
p.G139V	DO47509	SKCM	ICGC	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.2778
p.A131S	DO229045	LICA	ICGC	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.6477
p.E142D	DO232761	PBCA	ICGC	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1944
p.P136L	SIDM01078	Small Cell Lung Carcinoma	GDSC	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.7582
p.P136L	SHP-77	lung	COSMIC	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.7582
p.V123I	SIDM01145	Gastric Carcinoma	GDSC	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1667
p.V123I	SIDM00364	B-Lymphoblastic Leukemia	GDSC	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1667
p.V123I	SIDM01019	Acute Myeloid Leukemia	GDSC	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1667
p.V123I	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1667
p.V123I	NCI-SNU-16	stomach	COSMIC	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1667
p.V123I	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1667
p.V123I	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1667
p.V123I	IA-LM	lung	COSMIC	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.1667
p.I136T	ACH-000177	Prostate Cancer	CCLE	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.7078
p.I136T	NCI-H660	prostate	COSMIC	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation altering degron motif	0.7078
p.R126H	ACH-000559	Lung Cancer	CCLE	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.25
p.R126H	NCI-H1836	lung	COSMIC	RRASLSDIG	DEG_APCC_DBOX_1	129:137	Mutation rewiring degron network	0.25

Kaplan plot for CDK18 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDK18

UniProt ID: Q07002

Entrez ID: 5129

Protein name: Cyclin-dependent kinase 18 (EC 2.7.11.22) (Cell division protein kinase 18) (PCTAIRE-motif protein kinase 3) (Serine/threonine-protein kinase PCTAIRE-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDK18 in