DegronMD

Uniprot ID: Q07002

Source protein: Cyclin-dependent kinase 18

Source gene: CDK18

Class: DEG_APCC_DBOX_1

Location: 129:137

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8795

ASA_SCORE: 77.0667

COIL: 0.7771

CONS_SCORE: 0.6478

DSS_SCORE: 0.3005

HELIX: 0.1793

FCONS_SCORE: 0.9534

RIG_SCORE: 0.7194

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D132N	TCGA-56-A5DS	LUSC	TCGA	RRASLSDIG	DEG_APCC_DBOX_1	0.6932
p.S124G	TCGA-5C-A9VH	LIHC	TCGA	RRASLSDIG	DEG_APCC_DBOX_1	0.1944
p.E146D	TCGA-A5-A0G2	UCEC	TCGA	RRASLSDIG	DEG_APCC_DBOX_1	0.5278
p.R134H	TCGA-D1-A2G0	UCEC	TCGA	RRASLSDIG	DEG_APCC_DBOX_1	0.8244
p.S147N	TCGA-DA-A1I7	SKCM	TCGA	RRASLSDIG	DEG_APCC_DBOX_1	0.0556
p.R134S	TCGA-DA-A1IB	SKCM	TCGA	RRASLSDIG	DEG_APCC_DBOX_1	0.7427
p.E138D	TCGA-EO-A3B0	UCEC	TCGA	RRASLSDIG	DEG_APCC_DBOX_1	0.3056
p.G139V	DO233906	GACA	ICGC	RRASLSDIG	DEG_APCC_DBOX_1	0.2778
p.G139V	DO47509	SKCM	ICGC	RRASLSDIG	DEG_APCC_DBOX_1	0.2778
p.A131S	DO229045	LICA	ICGC	RRASLSDIG	DEG_APCC_DBOX_1	0.6477
p.E142D	DO232761	PBCA	ICGC	RRASLSDIG	DEG_APCC_DBOX_1	0.1944
p.P136L	SIDM01078	Small Cell Lung Carcinoma	GDSC	RRASLSDIG	DEG_APCC_DBOX_1	0.7582
p.P136L	SHP-77	lung	COSMIC	RRASLSDIG	DEG_APCC_DBOX_1	0.7582
p.V123I	SIDM01145	Gastric Carcinoma	GDSC	RRASLSDIG	DEG_APCC_DBOX_1	0.1667
p.V123I	SIDM00364	B-Lymphoblastic Leukemia	GDSC	RRASLSDIG	DEG_APCC_DBOX_1	0.1667
p.V123I	SIDM01019	Acute Myeloid Leukemia	GDSC	RRASLSDIG	DEG_APCC_DBOX_1	0.1667
p.V123I	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	RRASLSDIG	DEG_APCC_DBOX_1	0.1667
p.V123I	NCI-SNU-16	stomach	COSMIC	RRASLSDIG	DEG_APCC_DBOX_1	0.1667
p.V123I	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	RRASLSDIG	DEG_APCC_DBOX_1	0.1667
p.V123I	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	RRASLSDIG	DEG_APCC_DBOX_1	0.1667
p.V123I	IA-LM	lung	COSMIC	RRASLSDIG	DEG_APCC_DBOX_1	0.1667
p.I136T	ACH-000177	Prostate Cancer	CCLE	RRASLSDIG	DEG_APCC_DBOX_1	0.7078
p.I136T	NCI-H660	prostate	COSMIC	RRASLSDIG	DEG_APCC_DBOX_1	0.7078
p.R126H	ACH-000559	Lung Cancer	CCLE	RRASLSDIG	DEG_APCC_DBOX_1	0.25
p.R126H	NCI-H1836	lung	COSMIC	RRASLSDIG	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07002	Cyclin-dependent kinase 18	DEG_APCC_DBOX_1	129:137	RRASLSDIG	APC,CDC20,FZR1	0.8795	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRASLSDIG

Degron related mutations and impact score

Drug responses associated with CDK18 mutations

All proteins holding degron of RRASLSDIG