DegronMD - Q07617(SPAG1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P591S	TCGA-AA-3864	COAD	TCGA	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.1389
p.P591S	TCGA-AP-A1DK	UCEC	TCGA	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.1389
p.P591S	DO8490	COAD	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.1389
p.P591S	DO42033	UCEC	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.1389
p.A594D	TCGA-BR-6452	STAD	TCGA	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.0556
p.A594D	DO38404	STAD	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.0556
p.R566I	TCGA-EO-A22X	UCEC	TCGA	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.0556
p.R566I	DO43907	UCEC	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.0556
p.E570K	TCGA-FR-A8YC	SKCM	TCGA	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.1667
p.E570K	DO50301	SKCM	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.1667
p.R566T	TCGA-UY-A9PB	BLCA	TCGA	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.0556
p.R566T	DO219041	BLCA	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.0556
p.S589F	DO48396	BLCA	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.1944
p.E578A	DO233747	GACA	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation altering degron motif	0.659
p.P587S	DO230659	LAML	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	DO231140	LAML	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00434	Plasma Cell Myeloma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00570	Gastric Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00371	Pancreatic Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00611	Kidney Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00496	Thyroid Gland Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01259	B-Lymphoblastic Leukemia	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01005	Acute Myeloid Leukemia	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01112	Osteosarcoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00364	B-Lymphoblastic Leukemia	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00351	Oral Cavity Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00585	Hepatocellular Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00599	Osteosarcoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00375	Head and Neck Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00024	Non-Cancerous	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00488	Colorectal Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01146	Gastric Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00365	Small Cell Lung Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00242	Osteosarcoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00997	Thyroid Gland Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00970	Bladder Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01217	Other Blood Cancers	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00271	Gastric Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00217	Colorectal Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00289	B-Lymphoblastic Leukemia	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00579	Neuroblastoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00996	Thyroid Gland Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00316	Glioblastoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00381	Cervical Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00273	Glioblastoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01727	Chronic Myelogenous Leukemia	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01682	Gastric Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00167	Head and Neck Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01660	Kidney Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01622	Breast Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01368	Gastric Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01320	Pancreatic Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01336	Glioblastoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00166	Other Solid Cancers	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01464	Pancreatic Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01575	Plasma Cell Myeloma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01450	Gastric Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00173	Head and Neck Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01378	Ovarian Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01413	Oral Cavity Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01662	Plasma Cell Myeloma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01753	Gastric Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01574	Plasma Cell Myeloma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01756	Chronic Myelogenous Leukemia	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00162	Biliary Tract Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM01729	Endometrial Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.P587S	SIDM00497	Colorectal Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.A588S	DO229035	LICA	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.2222
p.P587T	DO229208	THCA	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.M569I	SIDM00333	Endometrial Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.1389
p.M569I	ACH-000988	Endometrial/Uterine Cancer	CCLE	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.1389
p.M569I	MFE-319	endometrium	COSMIC	WREKLSPIP	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPAG1

UniProt ID: Q07617

Entrez ID: 6674

Protein name: Sperm-associated antigen 1 (HSD-3.8) (Infertility-related sperm protein Spag-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPAG1 in