DegronMD

Uniprot ID: Q07617

Source protein: Sperm-associated antigen 1

Source gene: SPAG1

Class: DEG_APCC_DBOX_1

Location: 576:584

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9715

ASA_SCORE: 89.1556

COIL: 0.825

CONS_SCORE: 0.4396

DSS_SCORE: 0.3695

HELIX: 0.121

FCONS_SCORE: 1.1141

RIG_SCORE: 0.741

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P591S	TCGA-AA-3864	COAD	TCGA	WREKLSPIP	DEG_APCC_DBOX_1	0.1389
p.P591S	TCGA-AP-A1DK	UCEC	TCGA	WREKLSPIP	DEG_APCC_DBOX_1	0.1389
p.P591S	DO8490	COAD	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	0.1389
p.P591S	DO42033	UCEC	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	0.1389
p.A594D	TCGA-BR-6452	STAD	TCGA	WREKLSPIP	DEG_APCC_DBOX_1	0.0556
p.A594D	DO38404	STAD	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	0.0556
p.R566I	TCGA-EO-A22X	UCEC	TCGA	WREKLSPIP	DEG_APCC_DBOX_1	0.0556
p.R566I	DO43907	UCEC	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	0.0556
p.E570K	TCGA-FR-A8YC	SKCM	TCGA	WREKLSPIP	DEG_APCC_DBOX_1	0.1667
p.E570K	DO50301	SKCM	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	0.1667
p.R566T	TCGA-UY-A9PB	BLCA	TCGA	WREKLSPIP	DEG_APCC_DBOX_1	0.0556
p.R566T	DO219041	BLCA	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	0.0556
p.S589F	DO48396	BLCA	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	0.1944
p.E578A	DO233747	GACA	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	0.659
p.P587S	DO230659	LAML	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	DO231140	LAML	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00434	Plasma Cell Myeloma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00570	Gastric Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00371	Pancreatic Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00611	Kidney Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00496	Thyroid Gland Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01259	B-Lymphoblastic Leukemia	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01005	Acute Myeloid Leukemia	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01112	Osteosarcoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00364	B-Lymphoblastic Leukemia	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00351	Oral Cavity Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00585	Hepatocellular Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00599	Osteosarcoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00375	Head and Neck Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00024	Non-Cancerous	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00488	Colorectal Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01146	Gastric Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00365	Small Cell Lung Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00242	Osteosarcoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00997	Thyroid Gland Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00970	Bladder Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01217	Other Blood Cancers	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00271	Gastric Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00217	Colorectal Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00289	B-Lymphoblastic Leukemia	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00579	Neuroblastoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00996	Thyroid Gland Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00316	Glioblastoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00381	Cervical Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00273	Glioblastoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01727	Chronic Myelogenous Leukemia	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01682	Gastric Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00167	Head and Neck Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01660	Kidney Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01622	Breast Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01368	Gastric Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01320	Pancreatic Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01336	Glioblastoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00166	Other Solid Cancers	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01464	Pancreatic Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01575	Plasma Cell Myeloma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01450	Gastric Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00173	Head and Neck Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01378	Ovarian Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01413	Oral Cavity Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01662	Plasma Cell Myeloma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01753	Gastric Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01574	Plasma Cell Myeloma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01756	Chronic Myelogenous Leukemia	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00162	Biliary Tract Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM01729	Endometrial Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.P587S	SIDM00497	Colorectal Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.A588S	DO229035	LICA	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	0.2222
p.P587T	DO229208	THCA	ICGC	WREKLSPIP	DEG_APCC_DBOX_1	0.25
p.M569I	SIDM00333	Endometrial Carcinoma	GDSC	WREKLSPIP	DEG_APCC_DBOX_1	0.1389
p.M569I	ACH-000988	Endometrial/Uterine Cancer	CCLE	WREKLSPIP	DEG_APCC_DBOX_1	0.1389
p.M569I	MFE-319	endometrium	COSMIC	WREKLSPIP	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: WREKLSPIP

Degron related mutations and impact score

Drug responses associated with SPAG1 mutations

All proteins holding degron of WREKLSPIP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07617	Sperm-associated antigen 1	DEG_APCC_DBOX_1	576:584	WREKLSPIP	APC,CDC20,FZR1	0.9715	More...