DegronMD - Q08116(RGS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L54M	TCGA-37-3792	LUSC	TCGA	MIPHLE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.25
p.L54M	DO27192	LUSC	ICGC	MIPHLE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.25
p.D49Y	TCGA-A5-A0G2	UCEC	TCGA	MIPHLE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1111
p.D49Y	DO41235	UCEC	ICGC	MIPHLE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1111
p.S67Y	TCGA-AJ-A5DW	UCEC	TCGA	MIPHLE	LIG_APCC_ABBA_1	57:62	Mutation blocking phosphorylation signal	0.6389
p.S67Y	DO50075	UCEC	ICGC	MIPHLE	LIG_APCC_ABBA_1	57:62	Mutation blocking phosphorylation signal	0.6389
p.M65I	TCGA-FW-A3R5	SKCM	TCGA	MIPHLE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.25
p.M65I	DO37406	SKCM	ICGC	MIPHLE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.25
p.M65V	TCGA-IB-7651	PAAD	TCGA	MIPHLE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.25
p.M65V	DO46657	PAAD	ICGC	MIPHLE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.25
p.M50L	TCGA-L9-A443	LUAD	TCGA	MIPHLE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1389
p.M50L	DO24285	LUAD	ICGC	MIPHLE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1389
p.S67F	TCGA-VQ-A8P2	STAD	TCGA	MIPHLE	LIG_APCC_ABBA_1	57:62	Mutation blocking phosphorylation signal	0.6389
p.S67F	DO51761	STAD	ICGC	MIPHLE	LIG_APCC_ABBA_1	57:62	Mutation blocking phosphorylation signal	0.6389
p.A52G	DO52686	MALY	ICGC	MIPHLE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1944
p.S56C	DO52686	MALY	ICGC	MIPHLE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.3056
p.G47A	DO52686	MALY	ICGC	MIPHLE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.0556
p.D49N	DO52686	MALY	ICGC	MIPHLE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1111
p.R55I	DO52686	MALY	ICGC	MIPHLE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.2778
p.P59S	DO52686	MALY	ICGC	MIPHLE	LIG_APCC_ABBA_1	57:62	Mutation altering degron motif	0.6752
p.S70Y	SIDM01181	Hepatocellular Carcinoma	GDSC	MIPHLE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1111
p.S70Y	ACH-000221	Liver Cancer	CCLE	MIPHLE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1111
p.S70Y	SNU-398	liver	COSMIC	MIPHLE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1111

Kaplan plot for RGS1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RGS1

UniProt ID: Q08116

Entrez ID: 5996

Protein name: Regulator of G-protein signaling 1 (RGS1) (B-cell activation protein BL34) (Early response protein 1R20)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RGS1 in