DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
MIPHLE
Uniprot ID:
Q08116
Source protein:
Regulator of G-protein signaling 1
Source gene:
RGS1
Class:
LIG_APCC_ABBA_1
Location:
57:62
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9186
ASA_SCORE:
85.1
COIL:
0.7012
CONS_SCORE:
0.7458
DSS_SCORE:
0.4449
HELIX:
0.2738
FCONS_SCORE:
0.9708
RIG_SCORE:
0.7367
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L54M
TCGA-37-3792
LUSC
TCGA
MIPHLE
LIG_APCC_ABBA_1
0.25
p.L54M
DO27192
LUSC
ICGC
MIPHLE
LIG_APCC_ABBA_1
0.25
p.D49Y
TCGA-A5-A0G2
UCEC
TCGA
MIPHLE
LIG_APCC_ABBA_1
0.1111
p.D49Y
DO41235
UCEC
ICGC
MIPHLE
LIG_APCC_ABBA_1
0.1111
p.S67Y
TCGA-AJ-A5DW
UCEC
TCGA
MIPHLE
LIG_APCC_ABBA_1
0.6389
p.S67Y
DO50075
UCEC
ICGC
MIPHLE
LIG_APCC_ABBA_1
0.6389
p.M65I
TCGA-FW-A3R5
SKCM
TCGA
MIPHLE
LIG_APCC_ABBA_1
0.25
p.M65I
DO37406
SKCM
ICGC
MIPHLE
LIG_APCC_ABBA_1
0.25
p.M65V
TCGA-IB-7651
PAAD
TCGA
MIPHLE
LIG_APCC_ABBA_1
0.25
p.M65V
DO46657
PAAD
ICGC
MIPHLE
LIG_APCC_ABBA_1
0.25
p.M50L
TCGA-L9-A443
LUAD
TCGA
MIPHLE
LIG_APCC_ABBA_1
0.1389
p.M50L
DO24285
LUAD
ICGC
MIPHLE
LIG_APCC_ABBA_1
0.1389
p.S67F
TCGA-VQ-A8P2
STAD
TCGA
MIPHLE
LIG_APCC_ABBA_1
0.6389
p.S67F
DO51761
STAD
ICGC
MIPHLE
LIG_APCC_ABBA_1
0.6389
p.A52G
DO52686
MALY
ICGC
MIPHLE
LIG_APCC_ABBA_1
0.1944
p.S56C
DO52686
MALY
ICGC
MIPHLE
LIG_APCC_ABBA_1
0.3056
p.G47A
DO52686
MALY
ICGC
MIPHLE
LIG_APCC_ABBA_1
0.0556
p.D49N
DO52686
MALY
ICGC
MIPHLE
LIG_APCC_ABBA_1
0.1111
p.R55I
DO52686
MALY
ICGC
MIPHLE
LIG_APCC_ABBA_1
0.2778
p.P59S
DO52686
MALY
ICGC
MIPHLE
LIG_APCC_ABBA_1
0.6752
p.S70Y
SIDM01181
Hepatocellular Carcinoma
GDSC
MIPHLE
LIG_APCC_ABBA_1
0.1111
p.S70Y
ACH-000221
Liver Cancer
CCLE
MIPHLE
LIG_APCC_ABBA_1
0.1111
p.S70Y
SNU-398
liver
COSMIC
MIPHLE
LIG_APCC_ABBA_1
0.1111
Drug responses associated with RGS1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MIPHLE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q08116
Regulator of G-protein signaling 1
LIG_APCC_ABBA_1
57:62
MIPHLE
APC,CDC20,FZR1
0.9186
More...