DegronMD

Uniprot ID: Q08116

Source protein: Regulator of G-protein signaling 1

Source gene: RGS1

Class: LIG_APCC_ABBA_1

Location: 57:62

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9186

ASA_SCORE: 85.1

COIL: 0.7012

CONS_SCORE: 0.7458

DSS_SCORE: 0.4449

HELIX: 0.2738

FCONS_SCORE: 0.9708

RIG_SCORE: 0.7367

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P59S	DO52686	MALY	ICGC	MIPHLE	LIG_APCC_ABBA_1	0.6752
p.S67Y	TCGA-AJ-A5DW	UCEC	TCGA	MIPHLE	LIG_APCC_ABBA_1	0.6389
p.S67Y	DO50075	UCEC	ICGC	MIPHLE	LIG_APCC_ABBA_1	0.6389
p.S67F	TCGA-VQ-A8P2	STAD	TCGA	MIPHLE	LIG_APCC_ABBA_1	0.6389
p.S67F	DO51761	STAD	ICGC	MIPHLE	LIG_APCC_ABBA_1	0.6389
p.S56C	DO52686	MALY	ICGC	MIPHLE	LIG_APCC_ABBA_1	0.3056
p.R55I	DO52686	MALY	ICGC	MIPHLE	LIG_APCC_ABBA_1	0.2778
p.L54M	TCGA-37-3792	LUSC	TCGA	MIPHLE	LIG_APCC_ABBA_1	0.25
p.L54M	DO27192	LUSC	ICGC	MIPHLE	LIG_APCC_ABBA_1	0.25
p.M65I	TCGA-FW-A3R5	SKCM	TCGA	MIPHLE	LIG_APCC_ABBA_1	0.25
p.M65I	DO37406	SKCM	ICGC	MIPHLE	LIG_APCC_ABBA_1	0.25
p.M65V	TCGA-IB-7651	PAAD	TCGA	MIPHLE	LIG_APCC_ABBA_1	0.25
p.M65V	DO46657	PAAD	ICGC	MIPHLE	LIG_APCC_ABBA_1	0.25
p.A52G	DO52686	MALY	ICGC	MIPHLE	LIG_APCC_ABBA_1	0.1944
p.M50L	TCGA-L9-A443	LUAD	TCGA	MIPHLE	LIG_APCC_ABBA_1	0.1389
p.M50L	DO24285	LUAD	ICGC	MIPHLE	LIG_APCC_ABBA_1	0.1389
p.D49Y	TCGA-A5-A0G2	UCEC	TCGA	MIPHLE	LIG_APCC_ABBA_1	0.1111
p.D49Y	DO41235	UCEC	ICGC	MIPHLE	LIG_APCC_ABBA_1	0.1111
p.D49N	DO52686	MALY	ICGC	MIPHLE	LIG_APCC_ABBA_1	0.1111
p.S70Y	SIDM01181	Hepatocellular Carcinoma	GDSC	MIPHLE	LIG_APCC_ABBA_1	0.1111
p.S70Y	ACH-000221	Liver Cancer	CCLE	MIPHLE	LIG_APCC_ABBA_1	0.1111
p.S70Y	SNU-398	liver	COSMIC	MIPHLE	LIG_APCC_ABBA_1	0.1111
p.G47A	DO52686	MALY	ICGC	MIPHLE	LIG_APCC_ABBA_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08116	Regulator of G-protein signaling 1	LIG_APCC_ABBA_1	57:62	MIPHLE	APC,CDC20,FZR1	0.9186	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons