DegronMD - Q08499(PDE4D)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A161V	TCGA-AX-A2HC	UCEC	TCGA	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.3056
p.A161V	TCGA-EY-A1GL	UCEC	TCGA	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.3056
p.A161V	DO41572	UCEC	ICGC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.3056
p.A161V	DO41181	UCEC	ICGC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.3056
p.G158S	TCGA-CC-5258	LIHC	TCGA	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.2222
p.G158S	DO22881	LIHC	ICGC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.2222
p.M169T	TCGA-CK-5916	COAD	TCGA	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.7423
p.M169T	DO8786	COAD	ICGC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.7423
p.R163W	TCGA-D1-A16F	UCEC	TCGA	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.8634
p.R163W	DO233737	GACA	ICGC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.8634
p.R163W	DO42408	UCEC	ICGC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.8634
p.P165S	TCGA-DA-A1IC	SKCM	TCGA	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5641
p.P165S	DO37430	SKCM	ICGC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5641
p.Q179K	TCGA-DU-7294	LGG	TCGA	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.0833
p.Q179K	DO22333	LGG	ICGC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.0833
p.R163Q	TCGA-EY-A549	UCEC	TCGA	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.7329
p.R163Q	DO48174	UCEC	ICGC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.7329
p.S174F	TCGA-FS-A1ZK	SKCM	TCGA	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation blocking phosphorylation signal	0.6667
p.S174F	DO37474	SKCM	ICGC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation blocking phosphorylation signal	0.6667
p.I177V	DO231954	LICA	ICGC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1389
p.D167Y	SIDM00265	Ewing's Sarcoma	GDSC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.6214
p.D167Y	ES3	bone	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.6214
p.T180S	ACH-000126	Brain Cancer	CCLE	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.0556
p.R173Q	ACH-000895	Colon/Colorectal Cancer	CCLE	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.25
p.R173Q	ACH-000986	Colon/Colorectal Cancer	CCLE	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.25
p.R173Q	HT-115	large intestine	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.25
p.R173Q	CL-34	large intestine	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.25
p.R170Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.7329
p.V178I	SK-UT-1	soft tissue	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1111
p.R176Q	HT-115	large intestine	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.R176Q	CL-34	large intestine	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V170I	SK-UT-1	soft tissue	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.7076
p.V164I	SK-UT-1	soft tissue	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.7076
p.V169I	SK-UT-1	soft tissue	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.7076
p.V159A	AN3-CA	endometrium	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.25
p.V162A	AN3-CA	endometrium	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.6936
p.Y156H	NCI-H322M	lung	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.T157I	EN	endometrium	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1944

Kaplan plot for PDE4D in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDE4D

UniProt ID: Q08499

Entrez ID: 5144

Protein name: cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDE4D in