DegronMD

Uniprot ID: Q08499

Source protein: cAMP-specific 3',5'-cyclic phosphodiesterase 4D

Source gene: PDE4D

Class: DEG_APCC_DBOX_1

Location: 162:170

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9953

ASA_SCORE: 68.8889

COIL: 0.8582

CONS_SCORE: 0.3434

DSS_SCORE: 0.6183

HELIX: 0.0687

FCONS_SCORE: 1.0257

RIG_SCORE: 0.6424

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A161V	TCGA-AX-A2HC	UCEC	TCGA	GRSPLDPMT	DEG_APCC_DBOX_1	0.3056
p.A161V	TCGA-EY-A1GL	UCEC	TCGA	GRSPLDPMT	DEG_APCC_DBOX_1	0.3056
p.A161V	DO41572	UCEC	ICGC	GRSPLDPMT	DEG_APCC_DBOX_1	0.3056
p.A161V	DO41181	UCEC	ICGC	GRSPLDPMT	DEG_APCC_DBOX_1	0.3056
p.G158S	TCGA-CC-5258	LIHC	TCGA	GRSPLDPMT	DEG_APCC_DBOX_1	0.2222
p.G158S	DO22881	LIHC	ICGC	GRSPLDPMT	DEG_APCC_DBOX_1	0.2222
p.M169T	TCGA-CK-5916	COAD	TCGA	GRSPLDPMT	DEG_APCC_DBOX_1	0.7423
p.M169T	DO8786	COAD	ICGC	GRSPLDPMT	DEG_APCC_DBOX_1	0.7423
p.R163W	TCGA-D1-A16F	UCEC	TCGA	GRSPLDPMT	DEG_APCC_DBOX_1	0.8634
p.R163W	DO233737	GACA	ICGC	GRSPLDPMT	DEG_APCC_DBOX_1	0.8634
p.R163W	DO42408	UCEC	ICGC	GRSPLDPMT	DEG_APCC_DBOX_1	0.8634
p.P165S	TCGA-DA-A1IC	SKCM	TCGA	GRSPLDPMT	DEG_APCC_DBOX_1	0.5641
p.P165S	DO37430	SKCM	ICGC	GRSPLDPMT	DEG_APCC_DBOX_1	0.5641
p.Q179K	TCGA-DU-7294	LGG	TCGA	GRSPLDPMT	DEG_APCC_DBOX_1	0.0833
p.Q179K	DO22333	LGG	ICGC	GRSPLDPMT	DEG_APCC_DBOX_1	0.0833
p.R163Q	TCGA-EY-A549	UCEC	TCGA	GRSPLDPMT	DEG_APCC_DBOX_1	0.7329
p.R163Q	DO48174	UCEC	ICGC	GRSPLDPMT	DEG_APCC_DBOX_1	0.7329
p.S174F	TCGA-FS-A1ZK	SKCM	TCGA	GRSPLDPMT	DEG_APCC_DBOX_1	0.6667
p.S174F	DO37474	SKCM	ICGC	GRSPLDPMT	DEG_APCC_DBOX_1	0.6667
p.I177V	DO231954	LICA	ICGC	GRSPLDPMT	DEG_APCC_DBOX_1	0.1389
p.D167Y	SIDM00265	Ewing's Sarcoma	GDSC	GRSPLDPMT	DEG_APCC_DBOX_1	0.6214
p.D167Y	ES3	bone	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	0.6214
p.T180S	ACH-000126	Brain Cancer	CCLE	GRSPLDPMT	DEG_APCC_DBOX_1	0.0556
p.R173Q	ACH-000895	Colon/Colorectal Cancer	CCLE	GRSPLDPMT	DEG_APCC_DBOX_1	0.25
p.R173Q	ACH-000986	Colon/Colorectal Cancer	CCLE	GRSPLDPMT	DEG_APCC_DBOX_1	0.25
p.R173Q	HT-115	large_intestine	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	0.25
p.R173Q	CL-34	large_intestine	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	0.25
p.R170Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	GRSPLDPMT	DEG_APCC_DBOX_1	0.7329
p.V178I	SK-UT-1	soft_tissue	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	0.1111
p.R176Q	HT-115	large_intestine	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	0.1667
p.R176Q	CL-34	large_intestine	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	0.1667
p.V170I	SK-UT-1	soft_tissue	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	0.7076
p.V164I	SK-UT-1	soft_tissue	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	0.7076
p.V169I	SK-UT-1	soft_tissue	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	0.7076
p.V159A	AN3-CA	endometrium	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	0.25
p.V162A	AN3-CA	endometrium	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	0.6936
p.Y156H	NCI-H322M	lung	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	0.1667
p.T157I	EN	endometrium	COSMIC	GRSPLDPMT	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRSPLDPMT

Degron related mutations and impact score

Drug responses associated with PDE4D mutations

All proteins holding degron of GRSPLDPMT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08499	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	DEG_APCC_DBOX_1	162:170	GRSPLDPMT	APC,CDC20,FZR1	0.9953	More...