DegronMD - Q08554(DSC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P291A	TCGA-77-A5GB	LUSC	TCGA	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.25
p.P291A	DO45439	LUSC	ICGC	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.25
p.P298A	TCGA-CV-A45W	HNSC	TCGA	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation altering degron motif	0.6392
p.P298A	DO52060	HNSC	ICGC	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation altering degron motif	0.6392
p.S295Y	TCGA-DF-A2KN	UCEC	TCGA	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation altering degron motif	0.6009
p.S295Y	DO223282	UCEC	ICGC	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation altering degron motif	0.6009
p.D289Y	TCGA-DU-6392	LGG	TCGA	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.1944
p.D289Y	DO22237	LGG	ICGC	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.1944
p.H290Y	TCGA-EE-A29E	SKCM	TCGA	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.2222
p.H290Y	DO218847	SKCA	ICGC	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.2222
p.H290Y	DO37831	SKCM	ICGC	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.2222
p.P291Q	TCGA-FA-A4BB	DLBC	TCGA	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.25
p.P291Q	DO219885	DLBC	ICGC	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.25
p.K292N	TCGA-FI-A2D5	UCEC	TCGA	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.2778
p.K292N	DO41331	UCEC	ICGC	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.2778
p.P308L	TCGA-FS-A1Z3	SKCM	TCGA	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.0833
p.P308L	TCGA-WE-A8K5	SKCM	TCGA	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.0833
p.P308L	DO37635	SKCM	ICGC	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.0833
p.P308L	DO51282	SKCM	ICGC	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.0833
p.P308S	TCGA-IB-7651	PAAD	TCGA	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.0833
p.P308S	DO46657	PAAD	ICGC	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.0833
p.H297Y	TCGA-OL-A97C	BRCA	TCGA	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation altering degron motif	0.6118
p.H297Y	DO219640	BRCA	ICGC	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation altering degron motif	0.6118
p.G301S	DO222765	COCA	ICGC	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.2778
p.H293N	DO228974	LICA	ICGC	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.3056
p.Q286K	DO229045	LICA	ICGC	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.1111
p.P288L	DO222875	MELA	ICGC	FSIHPD	LIG_APCC_ABBA_1	294:299	Mutation rewiring degron network	0.1667

Kaplan plot for DSC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DSC1

UniProt ID: Q08554

Entrez ID: 1823

Protein name: Desmocollin-1 (Cadherin family member 1) (Desmosomal glycoprotein 2/3) (DG2/DG3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DSC1 in