DegronMD

Uniprot ID: Q08554

Source protein: Desmocollin-1

Source gene: DSC1

Class: LIG_APCC_ABBA_1

Location: 294:299

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5494

ASA_SCORE: 46.6

COIL: 0.3645

CONS_SCORE: 0.6019

DSS_SCORE: 0.4666

HELIX: 0.0105

FCONS_SCORE: 1.1216

RIG_SCORE: 0.7122

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P291A	TCGA-77-A5GB	LUSC	TCGA	FSIHPD	LIG_APCC_ABBA_1	0.25
p.P291A	DO45439	LUSC	ICGC	FSIHPD	LIG_APCC_ABBA_1	0.25
p.P298A	TCGA-CV-A45W	HNSC	TCGA	FSIHPD	LIG_APCC_ABBA_1	0.6392
p.P298A	DO52060	HNSC	ICGC	FSIHPD	LIG_APCC_ABBA_1	0.6392
p.S295Y	TCGA-DF-A2KN	UCEC	TCGA	FSIHPD	LIG_APCC_ABBA_1	0.6009
p.S295Y	DO223282	UCEC	ICGC	FSIHPD	LIG_APCC_ABBA_1	0.6009
p.D289Y	TCGA-DU-6392	LGG	TCGA	FSIHPD	LIG_APCC_ABBA_1	0.1944
p.D289Y	DO22237	LGG	ICGC	FSIHPD	LIG_APCC_ABBA_1	0.1944
p.H290Y	TCGA-EE-A29E	SKCM	TCGA	FSIHPD	LIG_APCC_ABBA_1	0.2222
p.H290Y	DO218847	SKCA	ICGC	FSIHPD	LIG_APCC_ABBA_1	0.2222
p.H290Y	DO37831	SKCM	ICGC	FSIHPD	LIG_APCC_ABBA_1	0.2222
p.P291Q	TCGA-FA-A4BB	DLBC	TCGA	FSIHPD	LIG_APCC_ABBA_1	0.25
p.P291Q	DO219885	DLBC	ICGC	FSIHPD	LIG_APCC_ABBA_1	0.25
p.K292N	TCGA-FI-A2D5	UCEC	TCGA	FSIHPD	LIG_APCC_ABBA_1	0.2778
p.K292N	DO41331	UCEC	ICGC	FSIHPD	LIG_APCC_ABBA_1	0.2778
p.P308L	TCGA-FS-A1Z3	SKCM	TCGA	FSIHPD	LIG_APCC_ABBA_1	0.0833
p.P308L	TCGA-WE-A8K5	SKCM	TCGA	FSIHPD	LIG_APCC_ABBA_1	0.0833
p.P308L	DO37635	SKCM	ICGC	FSIHPD	LIG_APCC_ABBA_1	0.0833
p.P308L	DO51282	SKCM	ICGC	FSIHPD	LIG_APCC_ABBA_1	0.0833
p.P308S	TCGA-IB-7651	PAAD	TCGA	FSIHPD	LIG_APCC_ABBA_1	0.0833
p.P308S	DO46657	PAAD	ICGC	FSIHPD	LIG_APCC_ABBA_1	0.0833
p.H297Y	TCGA-OL-A97C	BRCA	TCGA	FSIHPD	LIG_APCC_ABBA_1	0.6118
p.H297Y	DO219640	BRCA	ICGC	FSIHPD	LIG_APCC_ABBA_1	0.6118
p.G301S	DO222765	COCA	ICGC	FSIHPD	LIG_APCC_ABBA_1	0.2778
p.H293N	DO228974	LICA	ICGC	FSIHPD	LIG_APCC_ABBA_1	0.3056
p.Q286K	DO229045	LICA	ICGC	FSIHPD	LIG_APCC_ABBA_1	0.1111
p.P288L	DO222875	MELA	ICGC	FSIHPD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08554	Desmocollin-1	LIG_APCC_ABBA_1	294:299	FSIHPD	APC,CDC20,FZR1	0.5494	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons