DegronMD - Q08752(PPID)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L117F	TCGA-34-8456	LUSC	TCGA	DREGLLSMA	DEG_APCC_DBOX_1	113:121	Mutation altering degron motif	0.6981
p.L117F	DO219135	LUSC	ICGC	DREGLLSMA	DEG_APCC_DBOX_1	113:121	Mutation altering degron motif	0.6981
p.N107K	TCGA-AX-A0J0	UCEC	TCGA	DREGLLSMA	DEG_APCC_DBOX_1	113:121	Mutation rewiring degron network	0.1667
p.N107K	DO41133	UCEC	ICGC	DREGLLSMA	DEG_APCC_DBOX_1	113:121	Mutation rewiring degron network	0.1667
p.G129S	TCGA-B5-A5OC	UCEC	TCGA	DREGLLSMA	DEG_APCC_DBOX_1	113:121	Mutation rewiring degron network	0.1111
p.G129S	DO52405	UCEC	ICGC	DREGLLSMA	DEG_APCC_DBOX_1	113:121	Mutation rewiring degron network	0.1111
p.Q131P	DO10172	COAD	ICGC	DREGLLSMA	DEG_APCC_DBOX_1	113:121	Mutation rewiring degron network	0.0556
p.R125C	DO227976	COCA	ICGC	DREGLLSMA	DEG_APCC_DBOX_1	113:121	Mutation rewiring degron network	0.2222
p.A121E	DO229018	LICA	ICGC	DREGLLSMA	DEG_APCC_DBOX_1	113:121	Mutation altering degron motif	0.659
p.S119R	DO229041	LICA	ICGC	DREGLLSMA	DEG_APCC_DBOX_1	113:121	Mutation altering degron motif	0.6316
p.N122T	DO231799	LINC	ICGC	DREGLLSMA	DEG_APCC_DBOX_1	113:121	Mutation rewiring degron network	0.3056
p.M120T	SIDM01951	Colorectal Carcinoma	GDSC	DREGLLSMA	DEG_APCC_DBOX_1	113:121	Mutation altering degron motif	0.7423
p.N122D	SIDM00434	Plasma Cell Myeloma	GDSC	DREGLLSMA	DEG_APCC_DBOX_1	113:121	Mutation rewiring degron network	0.3056
p.N122D	ACH-000745	Myeloma	CCLE	DREGLLSMA	DEG_APCC_DBOX_1	113:121	Mutation rewiring degron network	0.3056
p.N122D	MOLP-8	haematopoietic and lymphoid tissue	COSMIC	DREGLLSMA	DEG_APCC_DBOX_1	113:121	Mutation rewiring degron network	0.3056
p.R114Q	SIDM01770	Gastric Carcinoma	GDSC	DREGLLSMA	DEG_APCC_DBOX_1	113:121	Mutation altering degron motif	0.7329
p.R114Q	ACH-000908	Gastric Cancer	CCLE	DREGLLSMA	DEG_APCC_DBOX_1	113:121	Mutation altering degron motif	0.7329
p.N128D	SIDM01611	Endometrial Carcinoma	GDSC	DREGLLSMA	DEG_APCC_DBOX_1	113:121	Mutation rewiring degron network	0.1389
p.N128D	ACH-000996	Endometrial/Uterine Cancer	CCLE	DREGLLSMA	DEG_APCC_DBOX_1	113:121	Mutation rewiring degron network	0.1389

Kaplan plot for PPID in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPID

UniProt ID: Q08752

Entrez ID: 5481

Protein name: Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC 5.2.1.8) (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Cyclophilin-related protein) (Rotamase D)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPID in