DegronMD

Uniprot ID: Q08752

Source protein: Peptidyl-prolyl cis-trans isomerase D

Source gene: PPID

Class: DEG_APCC_DBOX_1

Location: 113:121

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5162

ASA_SCORE: 41.5889

COIL: 0.4997

CONS_SCORE: 0.679

DSS_SCORE: 0.4607

HELIX: 0.0348

FCONS_SCORE: 1.0022

RIG_SCORE: 0.7747

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L117F	TCGA-34-8456	LUSC	TCGA	DREGLLSMA	DEG_APCC_DBOX_1	0.6981
p.L117F	DO219135	LUSC	ICGC	DREGLLSMA	DEG_APCC_DBOX_1	0.6981
p.N107K	TCGA-AX-A0J0	UCEC	TCGA	DREGLLSMA	DEG_APCC_DBOX_1	0.1667
p.N107K	DO41133	UCEC	ICGC	DREGLLSMA	DEG_APCC_DBOX_1	0.1667
p.G129S	TCGA-B5-A5OC	UCEC	TCGA	DREGLLSMA	DEG_APCC_DBOX_1	0.1111
p.G129S	DO52405	UCEC	ICGC	DREGLLSMA	DEG_APCC_DBOX_1	0.1111
p.Q131P	DO10172	COAD	ICGC	DREGLLSMA	DEG_APCC_DBOX_1	0.0556
p.R125C	DO227976	COCA	ICGC	DREGLLSMA	DEG_APCC_DBOX_1	0.2222
p.A121E	DO229018	LICA	ICGC	DREGLLSMA	DEG_APCC_DBOX_1	0.659
p.S119R	DO229041	LICA	ICGC	DREGLLSMA	DEG_APCC_DBOX_1	0.6316
p.N122T	DO231799	LINC	ICGC	DREGLLSMA	DEG_APCC_DBOX_1	0.3056
p.M120T	SIDM01951	Colorectal Carcinoma	GDSC	DREGLLSMA	DEG_APCC_DBOX_1	0.7423
p.N122D	SIDM00434	Plasma Cell Myeloma	GDSC	DREGLLSMA	DEG_APCC_DBOX_1	0.3056
p.N122D	ACH-000745	Myeloma	CCLE	DREGLLSMA	DEG_APCC_DBOX_1	0.3056
p.N122D	MOLP-8	haematopoietic_and_lymphoid_tissue	COSMIC	DREGLLSMA	DEG_APCC_DBOX_1	0.3056
p.R114Q	SIDM01770	Gastric Carcinoma	GDSC	DREGLLSMA	DEG_APCC_DBOX_1	0.7329
p.R114Q	ACH-000908	Gastric Cancer	CCLE	DREGLLSMA	DEG_APCC_DBOX_1	0.7329
p.N128D	SIDM01611	Endometrial Carcinoma	GDSC	DREGLLSMA	DEG_APCC_DBOX_1	0.1389
p.N128D	ACH-000996	Endometrial/Uterine Cancer	CCLE	DREGLLSMA	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08752	Peptidyl-prolyl cis-trans isomerase D	DEG_APCC_DBOX_1	113:121	DREGLLSMA	APC,CDC20,FZR1	0.5162	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons