DegronMD - Q08AM6(VAC14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P500S	TCGA-43-8118	LUSC	TCGA	SHSELQVPTP	DEG_COP1_1	491:500	Mutation altering degron motif	0.6752
p.P500S	DO45471	LUSC	ICGC	SHSELQVPTP	DEG_COP1_1	491:500	Mutation altering degron motif	0.6752
p.G501V	TCGA-44-7662	LUAD	TCGA	SHSELQVPTP	DEG_COP1_1	491:500	Mutation rewiring degron network	0.3056
p.G501V	TCGA-MA-AA43	CESC	TCGA	SHSELQVPTP	DEG_COP1_1	491:500	Mutation rewiring degron network	0.3056
p.G501V	DO219725	CESC	ICGC	SHSELQVPTP	DEG_COP1_1	491:500	Mutation rewiring degron network	0.3056
p.G501V	DO23597	LUAD	ICGC	SHSELQVPTP	DEG_COP1_1	491:500	Mutation rewiring degron network	0.3056
p.G510A	TCGA-GM-A2D9	BRCA	TCGA	SHSELQVPTP	DEG_COP1_1	491:500	Mutation rewiring degron network	0.0556
p.G510A	DO4810	BRCA	ICGC	SHSELQVPTP	DEG_COP1_1	491:500	Mutation rewiring degron network	0.0556
p.L483V	TCGA-VR-A8EQ	ESCA	TCGA	SHSELQVPTP	DEG_COP1_1	491:500	Mutation rewiring degron network	0.1111
p.G504S	DO11854	GBM	ICGC	SHSELQVPTP	DEG_COP1_1	491:500	Mutation rewiring degron network	0.2222
p.L495I	DO228974	LICA	ICGC	SHSELQVPTP	DEG_COP1_1	491:500	Mutation altering degron motif	0.6063
p.L495I	DO229045	LICA	ICGC	SHSELQVPTP	DEG_COP1_1	491:500	Mutation altering degron motif	0.6063
p.L495I	SIDM01445	Gastric Carcinoma	GDSC	SHSELQVPTP	DEG_COP1_1	491:500	Mutation altering degron motif	0.6063
p.L495I	ACH-000736	Gastric Cancer	CCLE	SHSELQVPTP	DEG_COP1_1	491:500	Mutation altering degron motif	0.6063
p.T508N	DO228974	LICA	ICGC	SHSELQVPTP	DEG_COP1_1	491:500	Mutation blocking phosphorylation signal	0.5556
p.D484N	DO229257	THCA	ICGC	SHSELQVPTP	DEG_COP1_1	491:500	Mutation rewiring degron network	0.1389
p.G501D	DO229213	THCA	ICGC	SHSELQVPTP	DEG_COP1_1	491:500	Mutation rewiring degron network	0.3056
p.P486A	SIDM00373	Endometrial Carcinoma	GDSC	SHSELQVPTP	DEG_COP1_1	491:500	Mutation rewiring degron network	0.1944
p.P486A	ACH-000974	Endometrial/Uterine Cancer	CCLE	SHSELQVPTP	DEG_COP1_1	491:500	Mutation rewiring degron network	0.1944
p.P486A	ACH-002026	Endometrial/Uterine Cancer	CCLE	SHSELQVPTP	DEG_COP1_1	491:500	Mutation rewiring degron network	0.1944
p.P486A	SNG-M	endometrium	COSMIC	SHSELQVPTP	DEG_COP1_1	491:500	Mutation rewiring degron network	0.1944
p.R502I	SIDM00789	Colorectal Carcinoma	GDSC	SHSELQVPTP	DEG_COP1_1	491:500	Mutation rewiring degron network	0.2778
p.R502I	ACH-000997	Colon/Colorectal Cancer	CCLE	SHSELQVPTP	DEG_COP1_1	491:500	Mutation rewiring degron network	0.2778
p.R502I	ACH-001061	Colon/Colorectal Cancer	CCLE	SHSELQVPTP	DEG_COP1_1	491:500	Mutation rewiring degron network	0.2778
p.R502I	HCT-15	large intestine	COSMIC	SHSELQVPTP	DEG_COP1_1	491:500	Mutation rewiring degron network	0.2778
p.G481A	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	SHSELQVPTP	DEG_COP1_1	491:500	Mutation rewiring degron network	0.0556
p.G481A	ACH-000371	Lymphoma	CCLE	SHSELQVPTP	DEG_COP1_1	491:500	Mutation rewiring degron network	0.0556
p.G481A	RL	haematopoietic and lymphoid tissue	COSMIC	SHSELQVPTP	DEG_COP1_1	491:500	Mutation rewiring degron network	0.0556
p.D487A	ACH-000864	Endometrial/Uterine Cancer	CCLE	SHSELQVPTP	DEG_COP1_1	491:500	Mutation rewiring degron network	0.2222

Kaplan plot for VAC14 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VAC14

UniProt ID: Q08AM6

Entrez ID: 55697

Protein name: Protein VAC14 homolog (Tax1-binding protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VAC14 in