DegronMD

Uniprot ID: Q08AM6

Source protein: Protein VAC14 homolog

Source gene: VAC14

Class: DEG_COP1_1

Location: 491:500

E3 ligase: COP1

DEGRON score: 0.7963

ASA_SCORE: 66.55

COIL: 0.6711

CONS_SCORE: 0.203

DSS_SCORE: 0.6916

HELIX: 0.186

FCONS_SCORE: 0.9916

RIG_SCORE: 0.6615

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P500S	TCGA-43-8118	LUSC	TCGA	SHSELQVPTP	DEG_COP1_1	0.6752
p.P500S	DO45471	LUSC	ICGC	SHSELQVPTP	DEG_COP1_1	0.6752
p.G501V	TCGA-44-7662	LUAD	TCGA	SHSELQVPTP	DEG_COP1_1	0.3056
p.G501V	TCGA-MA-AA43	CESC	TCGA	SHSELQVPTP	DEG_COP1_1	0.3056
p.G501V	DO219725	CESC	ICGC	SHSELQVPTP	DEG_COP1_1	0.3056
p.G501V	DO23597	LUAD	ICGC	SHSELQVPTP	DEG_COP1_1	0.3056
p.G510A	TCGA-GM-A2D9	BRCA	TCGA	SHSELQVPTP	DEG_COP1_1	0.0556
p.G510A	DO4810	BRCA	ICGC	SHSELQVPTP	DEG_COP1_1	0.0556
p.L483V	TCGA-VR-A8EQ	ESCA	TCGA	SHSELQVPTP	DEG_COP1_1	0.1111
p.G504S	DO11854	GBM	ICGC	SHSELQVPTP	DEG_COP1_1	0.2222
p.L495I	DO228974	LICA	ICGC	SHSELQVPTP	DEG_COP1_1	0.6063
p.L495I	DO229045	LICA	ICGC	SHSELQVPTP	DEG_COP1_1	0.6063
p.L495I	SIDM01445	Gastric Carcinoma	GDSC	SHSELQVPTP	DEG_COP1_1	0.6063
p.L495I	ACH-000736	Gastric Cancer	CCLE	SHSELQVPTP	DEG_COP1_1	0.6063
p.T508N	DO228974	LICA	ICGC	SHSELQVPTP	DEG_COP1_1	0.5556
p.D484N	DO229257	THCA	ICGC	SHSELQVPTP	DEG_COP1_1	0.1389
p.G501D	DO229213	THCA	ICGC	SHSELQVPTP	DEG_COP1_1	0.3056
p.P486A	SIDM00373	Endometrial Carcinoma	GDSC	SHSELQVPTP	DEG_COP1_1	0.1944
p.P486A	ACH-000974	Endometrial/Uterine Cancer	CCLE	SHSELQVPTP	DEG_COP1_1	0.1944
p.P486A	ACH-002026	Endometrial/Uterine Cancer	CCLE	SHSELQVPTP	DEG_COP1_1	0.1944
p.P486A	SNG-M	endometrium	COSMIC	SHSELQVPTP	DEG_COP1_1	0.1944
p.R502I	SIDM00789	Colorectal Carcinoma	GDSC	SHSELQVPTP	DEG_COP1_1	0.2778
p.R502I	ACH-000997	Colon/Colorectal Cancer	CCLE	SHSELQVPTP	DEG_COP1_1	0.2778
p.R502I	ACH-001061	Colon/Colorectal Cancer	CCLE	SHSELQVPTP	DEG_COP1_1	0.2778
p.R502I	HCT-15	large_intestine	COSMIC	SHSELQVPTP	DEG_COP1_1	0.2778
p.G481A	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	SHSELQVPTP	DEG_COP1_1	0.0556
p.G481A	ACH-000371	Lymphoma	CCLE	SHSELQVPTP	DEG_COP1_1	0.0556
p.G481A	RL	haematopoietic_and_lymphoid_tissue	COSMIC	SHSELQVPTP	DEG_COP1_1	0.0556
p.D487A	ACH-000864	Endometrial/Uterine Cancer	CCLE	SHSELQVPTP	DEG_COP1_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SHSELQVPTP

Degron related mutations and impact score

Drug responses associated with VAC14 mutations

All proteins holding degron of SHSELQVPTP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08AM6	Protein VAC14 homolog	DEG_COP1_1	491:500	SHSELQVPTP	COP1	0.7963	More...